Rabbit anti-Cattle Interferon Tau (IFNt) Polyclonal Antibody | anti-IFNt antibody

Polyclonal Antibody to Interferon Tau (IFNt)

Cat. Num. AAA2112167

• Gene Names: IFNT2; IFNT; TP-1; IFNT1; IFN-tau-c2
• Reactivity: Cattle
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation
• Purity: Antigen-specific affinity chromatography followed by Protein A affinity chromatography
• Synonyms: Interferon Tau (IFNt); Polyclonal Antibody; Polyclonal Antibody to Interferon Tau (IFNt); IFN-T1; TP1; OTP; Trophoblastin; Interferon Tau-1; Trophoblast Protein 1; Trophoblast Antiluteolytic Protein; Antiluteolysin; anti-IFNt antibody

• Host: Rabbit
• Reactivity: Cattle
• Clonality: Polyclonal
• Specificity: The antibody is a rabbit polyclonal antibody raised against IFNt. It has been selected for its ability to recognize IFNt in immunohistochemical staining and western blotting.
• Purity/Purification: Antigen-specific affinity chromatography followed by Protein A affinity chromatography
• Form/Format: Liquid; PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
• Concentration: 500ug/ml (varies by lot)
• Sequence: Cys24~Leu195

• Applicable Applications for anti-IFNt antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
• Application Notes: WB: 0.5-2ug/mL; IHC: 5-20ug/mL; ICC: 5-20ug/mL
• Immunogen Sequence: Cys24~Leu195
• Cross Reactivity: Cattle
• Conjugation: None
• Preparation and Storage: Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.; Avoid repeated freeze/thaw cycles.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Western Blot (WB)

(Western Blot; Sample: Recombinant IFNt, Bovine.)

Product Categories/Family for anti-IFNt antibody

Human Gene Deletion

NCBI and Uniprot Product Information

• NCBI GI #: 269973909
• NCBI GeneID: 317698
• NCBI Accession #: NP_001015511.3
• NCBI GenBank Nucleotide #: NM_001015511.3
• UniProt Accession #: P15696; P15694; Q28126; Q28127; Q28128; Q28191; Q95NE2; P56830
• Molecular Weight: 22,134 Da
• NCBI Official Full Name: interferon tau-2
• NCBI Official Symbol: IFNT2
• NCBI Official Synonym Symbols: IFNT; TP-1; IFNT1; IFN-tau-c2
• NCBI Protein Information: interferon tau-2
• UniProt Protein Name: Interferon tau-1
• Protein Family: Interferon
• UniProt Gene Name: IFNT1
• UniProt Synonym Gene Names: IFN-tau-1; TP-1
• UniProt Entry Name: IFNT1_BOVIN

Uniprot Description

Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.