Rabbit anti-Human Integrin beta2 Polyclonal Antibody | anti-ITGB2 antibody

Integrin beta2 Polyclonal Antibody

Cat. Num. AAA3007125

• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Integrin beta2; Polyclonal Antibody; Integrin beta2 Polyclonal Antibody; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150; 95 subunit bet; Complement receptor C3 subunit beta; CD18; ITGB2; MFI7; anti-ITGB2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ITGB2 polyclonal antibody detects endogenous levels of ITGB2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 769

• Applicable Applications for anti-ITGB2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human ITGB2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of ITGB2 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate)

Related Product Information for anti-ITGB2 antibody

The small inducible genes (SIG) family encodes proteins that are involved in overlapping processes of inflammation, immune response, wound repair and coagulation. The SIG family contains two branches, designated CXC and CC, distinguished by whether or not the first two of four conserved cysteine residues are separated by an additional amino acid residue. The CXC SIGs map to human chromosome 4, including those encoding beta-thromboglobulin and platelet factor 4 (PF4), which are both expressed by megakaryocytes in a tissue-specific fashion and duplicated, there being a PF4 and a PF4alt gene, and a beta TG1 and beta TG2 gene. PPBPL1 (pro-platelet basic protein-like 1), also known as TGB2 (thromboglobulin, beta-2), belongs to the SIG family and is a CXC SIG protein, which contains four cysteine residues separated by a single amino acid residue. PPBPL1 is closely linked to other PPBPs, PF4s and several other CXC SIGs in a 700-kb Sfi1 fragment that localizes to chromosome 4q12-q13.

NCBI and Uniprot Product Information

• NCBI GI #: 89191865
• NCBI Accession #: NP_000202.2
• NCBI GenBank Nucleotide #: NP_000202.2
• UniProt Accession #: P05107
• Molecular Weight: ~ 95kDa
• NCBI Official Full Name: integrin beta-2
• UniProt Protein Name: Integrin beta-2
• Protein Family: Integrin
• UniProt Gene Name: ITGB2
• UniProt Synonym Gene Names: CD18; MFI7
• UniProt Entry Name: ITB2_HUMAN

Uniprot Description

ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1).

Protein type: Receptor, misc.; Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Cell surface

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cell surface; membrane; plasma membrane; integrin complex; receptor complex; vesicle; lipid raft

Molecular Function: protein binding; protein heterodimerization activity; metal ion binding; protein complex binding; cell adhesion molecule binding; ICAM-3 receptor activity; glycoprotein binding; protein kinase binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; apoptosis; cell-matrix adhesion; natural killer cell activation; receptor clustering; activation of NF-kappaB transcription factor; regulation of cell shape; leukocyte adhesion; cellular extravasation; cell-cell signaling; inflammatory response; cell adhesion; regulation of peptidyl-tyrosine phosphorylation; toll-like receptor 4 signaling pathway; aging; integrin-mediated signaling pathway; neutrophil chemotaxis; regulation of immune response; activated T cell proliferation; leukocyte migration during inflammatory response; heterotypic cell-cell adhesion; positive regulation of angiogenesis; toll-like receptor signaling pathway; endothelial cell migration; innate immune response; blood coagulation; leukocyte migration

Disease: Leukocyte Adhesion Deficiency, Type I