Western Blot (WB)
(Anti-CD18 Picoband antibody, MBS177408, Western blottingAll lanes: Anti CD18 (MBS177408) at 0.5ug/mlWB: Recombinant Human CD18 Protein 0.5ngPredicted bind size: 40KDObserved bind size: 40KD )
Rabbit Integrin beta-2 Polyclonal Antibody | anti-ITGB2 antibody
Anti-CD18 Antibody
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human
Western Blot (WB)
(Anti-CD18 Picoband antibody, MBS177408, Western blottingAll lanes: Anti CD18 (MBS177408) at 0.5ug/mlWB: Recombinant Human CD18 Protein 0.5ngPredicted bind size: 40KDObserved bind size: 40KD )
Western Blot (WB)
(Anti-CD18 Picoband antibody, MBS177408, Western blottingAll lanes: Anti CD18 (MBS177408) at 0.5ug/mlWB: Recombinant Human CD18 Protein 0.5ngPredicted bind size: 40KDObserved bind size: 40KD )
Immunohistochemistry (IHC)
(Anti-CD18 Picoband antibody, MBS177408, IHC(P)All lanes: Anti CD18 (MBS177408) at 0.5ug/mlLane 1: JURKAT Whole Cell Lysate at 40ugLane 2: CEM Whole Cell Lysate at 40ugPredicted bind size: 85KDObserved bind size: 100KD )
Immunohistochemistry (IHC)
(Anti-CD18 Picoband antibody, MBS177408, IHC(P)All lanes: Anti CD18 (MBS177408) at 0.5ug/mlLane 1: JURKAT Whole Cell Lysate at 40ugLane 2: CEM Whole Cell Lysate at 40ugPredicted bind size: 85KDObserved bind size: 100KD )
Immunohistochemistry (IHC)
(Anti-CD18 Picoband antibody, MBS177408, IHC(P)IHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-CD18 Picoband antibody, MBS177408, IHC(P)IHC(P): Human Lung Cancer Tissue )
Immunocytochemistry (ICC)
(Anti-CD18 Picoband antibody, MBS177408-1, ICCICC: SMMC7721 Cell )
Immunocytochemistry (ICC)
(Anti-CD18 Picoband antibody, MBS177408-1, ICCICC: SMMC7721 Cell )
Background: ITGB2(INTEGRIN, BETA-2), also known as CD18, is a protein that in humans is encoded by the ITGB2 gene. ITGB2 is an integrin protein that belongs to the class of cell membrane glycoproteins. The beta-2 integrin chain gene is designated ITGB2 and the leukocyte antigen has been designated CD18. The ITGB2 gene is mapped to 21q22.3. The expression of CD18 is increased in lymphoblastoid cells from persons with Down syndrome, consistent with the location of the gene on chromosome 21. In humans lack of ITGB2 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. Although ITGB2 is expressed on the cell surface at normal levels and is capable of function following extracellular stimulation, it could not be activated via the 'inside-out' signaling pathways.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Description
ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1).
Protein type: Cell surface; Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cell surface; membrane; plasma membrane; integrin complex; vesicle; receptor complex; lipid raft
Molecular Function: protein binding; protein heterodimerization activity; metal ion binding; protein complex binding; cell adhesion molecule binding; ICAM-3 receptor activity; glycoprotein binding; protein kinase binding
Biological Process: extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; apoptosis; cell-matrix adhesion; natural killer cell activation; receptor clustering; activation of NF-kappaB transcription factor; regulation of cell shape; leukocyte adhesion; cellular extravasation; cell-cell signaling; inflammatory response; cell adhesion; toll-like receptor 4 signaling pathway; regulation of peptidyl-tyrosine phosphorylation; aging; integrin-mediated signaling pathway; neutrophil chemotaxis; regulation of immune response; activated T cell proliferation; leukocyte migration during inflammatory response; heterotypic cell-cell adhesion; positive regulation of angiogenesis; toll-like receptor signaling pathway; innate immune response; endothelial cell migration; blood coagulation; leukocyte migration
Disease: Leukocyte Adhesion Deficiency, Type I
Research Articles on ITGB2
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Product Notes
The ITGB2 itgb2 (Catalog #AAA177408) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD18 Antibody reacts with Human. No cross reactivity with other proteins. and may cross-react with other species as described in the data sheet. AAA Biotech's Integrin beta-2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC-P). Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human. Researchers should empirically determine the suitability of the ITGB2 itgb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Integrin beta-2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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