Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Liver Tissue; Lane2: Mouse Lung Tissue.)
Rabbit anti-Mouse Integrin Beta 1 (ITGb1) Polyclonal Antibody | anti-ITGb1 antibody
Polyclonal Antibody to Integrin Beta 1 (ITGb1)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-VEVVLQF ICKCNCQSHG IPASPKCHEG NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK RDNTNEIYSG KFCECDNFNC DRSNGLICGG NGVCRCRVCE CYPNYTGSAC DCSLDTGPCL ASNGQICNGR GICECGACKC TDPKFQGPTC ETCQTCLGVC AEHKECVQCR AFNKGEKKDT CAQECSHFNL TKVESREKLP QPVQVDPVTH CKEKDIDDCW FYFTYSVNGN NEAI
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Liver Tissue; Lane2: Mouse Lung Tissue.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Liver Tissue; Lane2: Mouse Lung Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant ITGb1, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant ITGb1, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Mouse Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Mouse Tissue))
NCBI and Uniprot Product Information
Uniprot Description
ITGB1: an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. . Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle).
Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 8|8 E2
Cellular Component: acrosomal vesicle; adherens junction; basement membrane; cell junction; cell projection; cell surface; cytoplasm; cytoplasmic vesicle; dendritic spine; endosome; external side of plasma membrane; extracellular exosome; filopodium; focal adhesion; hemidesmosome; integral component of membrane; integrin alpha1-beta1 complex; integrin alpha10-beta1 complex; integrin alpha11-beta1 complex; integrin alpha2-beta1 complex; integrin alpha3-beta1 complex; integrin alpha7-beta1 complex; integrin alpha9-beta1 complex; integrin complex; intercalated disc; intercellular junction; invadopodium membrane; membrane; membrane raft; neuromuscular junction; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; receptor complex; sarcolemma; synapse
Molecular Function: actin binding; alpha-actinin binding; C-X3-C chemokine binding; cadherin binding; cell adhesion molecule binding; collagen binding; collagen binding involved in cell-matrix adhesion; fibronectin binding; integrin binding; kinase binding; laminin binding; metal ion binding; peptide binding; protease binding; protein binding; protein complex binding; protein domain specific binding; protein heterodimerization activity; protein kinase binding; receptor activity; receptor binding
Biological Process: axon extension; basement membrane organization; calcium-independent cell-matrix adhesion; cardiac muscle cell differentiation; cardiac muscle tissue development; cell adhesion; cell adhesion mediated by integrin; cell fate specification; cell migration; cell migration during sprouting angiogenesis; cell-matrix adhesion; cell-substrate adhesion; cellular calcium ion homeostasis; cellular response to low-density lipoprotein particle stimulus; dendrite morphogenesis; formation of radial glial scaffolds; G1/S transition of mitotic cell cycle; germ cell migration; heterotypic cell-cell adhesion; in utero embryonic development; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte tethering or rolling; negative regulation of anoikis; negative regulation of cell differentiation; negative regulation of cell projection organization; negative regulation of cell proliferation; negative regulation of neuron differentiation; negative regulation of Rho protein signal transduction; neuron projection development; positive regulation of angiogenesis; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-substrate adhesion; positive regulation of endocytosis; positive regulation of GTPase activity; positive regulation of MAPK cascade; positive regulation of neuron differentiation; positive regulation of neuron projection development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of receptor activity; protein transport within lipid bilayer; receptor internalization; regulation of cell cycle; regulation of collagen catabolic process; regulation of G-protein coupled receptor protein signaling pathway; sarcomere organization; stress fiber assembly; tissue homeostasis; transforming growth factor beta receptor signaling pathway; visual learning
Research Articles on ITGb1
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Product Notes
The ITGb1 itgb1 (Catalog #AAA2002585) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Integrin Beta 1 (ITGb1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Integrin Beta 1 (ITGb1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the ITGb1 itgb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-VEV VLQF ICKCNCQSHG IPASPKCHEG NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK RDNTNEIYSG KFCECDNFNC DRSNGLICGG NGVCRCRVCE CYPNYTGSAC DCSLDTGPCL ASNGQICNGR GICECGACKC TDPKFQGPTC ETCQTCLGVC AEHKECVQCR AFNKGEKKDT CAQECSHFNL TKVESREKLP QPVQVDPVTH CKEKDIDDCW FYFTYSVNGN NEAI. It is sometimes possible for the material contained within the vial of "Integrin Beta 1 (ITGb1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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