Testing Data
(A431 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with MBS610369 Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP)
Rabbit Integrin alpha3 Polyclonal Antibody | anti-ITGA3 antibody
Integrin alpha3 (CD49c, Very Late Antigen3a chain, VLA3a)
Serum
Serum
Dilution: ELISA/RIA: 1:1000
Western Blot: 1:500 Detects Intergrin alpha 3 on 10ug of A431 lysates.
Immunoprecipitation: 5ul precipitates alpha3/beta1 from 5x10e6 cells.
Immunohistochemistry/Immunofluorescence: 1:500; acetone-fixed tissue sections
Testing Data
(A431 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with MBS610369 Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP)
Testing Data
(A431 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with MBS610369 Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP)
Testing Data
(A431 (Lane1) and C2C12 lysate (Lane2) were resolved by electrophoresis, transferred to PVDF membrane and probed with MBS610369.)
Testing Data
(A431 (Lane1) and C2C12 lysate (Lane2) were resolved by electrophoresis, transferred to PVDF membrane and probed with MBS610369.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Uniprot Description
ITGA3: an integral membrane protein that heterodimerizes with a beta chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. Undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1. Two alternatively spliced isoforms have been described.
Protein type: Cell adhesion; Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component: filopodium membrane; growth cone; focal adhesion; cell surface; perinuclear region of cytoplasm; basolateral plasma membrane; plasma membrane; excitatory synapse; integrin complex; receptor complex; external side of plasma membrane
Molecular Function: integrin binding; collagen binding; protein domain specific binding; protein binding; protease binding; protein heterodimerization activity; metal ion binding; fibronectin binding; laminin binding; glycoprotein binding
Biological Process: response to drug; skin development; integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; maternal process involved in pregnancy; cell-matrix adhesion; heart development; regulation of BMP signaling pathway; regulation of Wnt receptor signaling pathway; neuron migration; mesodermal cell differentiation; memory; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of Rho protein signal transduction; blood coagulation; leukocyte migration; negative regulation of cell projection organization and biogenesis; lung development
Disease: Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital
Research Articles on ITGA3
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Product Notes
The ITGA3 itga3 (Catalog #AAA610369) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Integrin alpha3 (CD49c, Very Late Antigen3a chain, VLA3a) reacts with Bovine, Canine, Chicken, Equine, Goat, Hamster, Human, Mouse, Porcine, Rat, Sheep and may cross-react with other species as described in the data sheet. AAA Biotech's Integrin alpha3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF), Radioimmunoassay (RIA). Suitable for use in ELISA, RIA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunofluorescence. Dilution: ELISA/RIA: 1:1000 Western Blot: 1:500 Detects Intergrin alpha 3 on 10ug of A431 lysates. Immunoprecipitation: 5ul precipitates alpha3/beta1 from 5x10e6 cells. Immunohistochemistry/Immunofluorescence: 1:500; acetone-fixed tissue sections. Researchers should empirically determine the suitability of the ITGA3 itga3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Integrin alpha3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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