Western Blot (WB)
(Western Blot: Sample: Lane1: Human A549 Cells; Lane2: Human Hela Cells.)
Rabbit anti-Mouse Integrin Alpha V Polyclonal Antibody | anti-ITGaV antibody
Polyclonal Antibody to Integrin Alpha V (ITGaV)
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Lane1: Human A549 Cells; Lane2: Human Hela Cells.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Human A549 Cells; Lane2: Human Hela Cells.)
Western Blot (WB)
(Western Blot: Sample: Recombinant ITGaV, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant ITGaV, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Testis Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Testis Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]
Uniprot Description
ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2 D|2 49.33 cM
Cellular Component: cell junction; cell surface; cytosol; external side of plasma membrane; filopodium membrane; focal adhesion; integral component of membrane; integrin complex; membrane; microvillus membrane; nucleus; plasma membrane
Molecular Function: C-X3-C chemokine binding; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; insulin-like growth factor I binding; metal ion binding; opsonin binding; peptide binding; protease binding; protein heterodimerization activity; protein kinase C binding; receptor binding; voltage-gated calcium channel activity
Biological Process: angiogenesis; apoptotic cell clearance; blood vessel development; cell adhesion; cell adhesion mediated by integrin; cell differentiation; cell growth; cell migration; cell-matrix adhesion; cell-substrate adhesion; cellular calcium ion homeostasis; detection of molecule of bacterial origin; elevation of cytosolic calcium ion concentration; endothelial cell migration; entry of virus into host cell; fertilization; focal adhesion assembly; gonad morphogenesis; heterotypic cell-cell adhesion; inflammatory response; integrin-mediated signaling pathway; multicellular organism development; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of MAPK cascade; positive regulation of osteoblast proliferation; regulation of bone resorption; regulation of phagocytosis; release of sequestered calcium ion into cytosol; T cell activation
Research Articles on ITGaV
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Product Notes
The ITGaV itgav (Catalog #AAA2027915) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Integrin Alpha V (ITGaV) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Integrin Alpha V can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-2ug/ml Immunocytochemistry in formalin fixed cells: 5-20ug/ml Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml Immunohistochemistry in paraffin section: 5-20ug/ml Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the ITGaV itgav for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Integrin Alpha V, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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