Flow Cytometry (FC/FACS)
(C57BL/6 murine bone marrow cells are stained with PE Anti-Mouse CD51 Antibody[Used at 0.2ug/106 cells dilution] (filled gray histogram). Unstained bone marrow cells (empty black histogram) are used as control.)
Rat anti-Mouse CD51 Monoclonal Antibody | anti-CD51 antibody
PE Anti-Mouse CD51 Antibody[RMV-7]
Flow Cytometry (FC/FACS)
(C57BL/6 murine bone marrow cells are stained with PE Anti-Mouse CD51 Antibody[Used at 0.2ug/106 cells dilution] (filled gray histogram). Unstained bone marrow cells (empty black histogram) are used as control.)
Flow Cytometry (FC/FACS)
(C57BL/6 murine bone marrow cells are stained with PE Anti-Mouse CD51 Antibody[Used at 0.2ug/106 cells dilution] (filled gray histogram). Unstained bone marrow cells (empty black histogram) are used as control.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]
Uniprot Description
ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: filopodium membrane; cell surface; focal adhesion; membrane; microvillus membrane; integral to membrane; plasma membrane; intracellular; cytosol; nucleus; integrin complex; external side of plasma membrane
Molecular Function: voltage-gated calcium channel activity; opsonin binding; insulin-like growth factor I binding; protease binding; protein kinase C binding; extracellular matrix binding; protein heterodimerization activity; metal ion binding; fibronectin binding; peptide binding; receptor binding
Biological Process: negative regulation of lipid transport; focal adhesion formation; entry of virus into host cell; positive regulation of cell adhesion; T cell activation; cell-matrix adhesion; multicellular organismal development; negative chemotaxis; gonad morphogenesis; regulation of phagocytosis; elevation of cytosolic calcium ion concentration; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; angiogenesis; cell growth; cell adhesion; inflammatory response; cell differentiation; integrin-mediated signaling pathway; blood vessel development; cell migration; regulation of bone resorption; negative regulation of lipoprotein metabolic process; detection of molecule of bacterial origin; cell-substrate adhesion; cellular calcium ion homeostasis; heterotypic cell-cell adhesion; fertilization; negative regulation of low-density lipoprotein receptor biosynthetic process; release of sequestered calcium ion into cytosol; positive regulation of osteoblast proliferation; endothelial cell migration; apoptotic cell clearance; positive regulation of cell migration
Research Articles on CD51
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Product Notes
The CD51 itgav (Catalog #AAA2563726) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The PE Anti-Mouse CD51 Antibody[RMV-7] reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD51 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS/FCM). Researchers should empirically determine the suitability of the CD51 itgav for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD51, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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