Western Blot (WB)
(Western Blot: Sample: Recombinant IGFBP3, Mouse.)
Rabbit Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Polyclonal Antibody | anti-IGFBP3 antibody
Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3)
MGHHHHHHSGSEF-SQVVPSTHRV TDSKFHPLHA KMDVIKKGHA RDSQRYKVDY ESQSTDTQNF SSESKRETEY GPCRREMEDT LNHLKFLNVL SPRGVHIPNC DKKGFYKKKR CRPSKGRKQS FCWCVDKYGQ RLPGYDTKGK DDVHCLSVQS Q
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.
Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Western Blot (WB)
(Western Blot: Sample: Recombinant IGFBP3, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant IGFBP3, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue)
NCBI and Uniprot Product Information
Uniprot Description
IGFBP3: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11 A1|11 4.75 cM
Cellular Component: extracellular exosome; extracellular region; extracellular space; nuclear heterochromatin; nucleus
Molecular Function: fibronectin binding; growth factor binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; protein tyrosine phosphatase activator activity
Biological Process: negative regulation of cell proliferation; negative regulation of protein phosphorylation; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; negative regulation of testosterone secretion; osteoblast differentiation; positive regulation of apoptosis; positive regulation of cardiac muscle cell apoptotic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of myoblast differentiation; protein amino acid phosphorylation; regulation of cell growth; regulation of glucose metabolic process; regulation of growth; type B pancreatic cell proliferation
Research Articles on IGFBP3
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Product Notes
The IGFBP3 igfbp3 (Catalog #AAA2002902) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3) reacts with Mus musculus (Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's Insulin Like Growth Factor Binding Protein 3 (IGFBP3) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP). Western blotting: 0.5-2ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the IGFBP3 igfbp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF-SQVVPS THRV TDSKFHPLHA KMDVIKKGHA RDSQRYKVDY ESQSTDTQNF SSESKRETEY GPCRREMEDT LNHLKFLNVL SPRGVHIPNC DKKGFYKKKR CRPSKGRKQS FCWCVDKYGQ RLPGYDTKGK DDVHCLSVQS Q. It is sometimes possible for the material contained within the vial of "Insulin Like Growth Factor Binding Protein 3 (IGFBP3), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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