Rabbit anti-Mouse Insulin Polyclonal Antibody | anti-INS antibody

Insulin Polyclonal Antibody

Cat. Num. AAA2556221

• Gene Names: Ins1; Ins-1; Ins2-rs1
• Reactivity: Mouse
• Applications: Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: Insulin; Polyclonal Antibody; Insulin Polyclonal Antibody; IDDM; IDDM1; IDDM2; ILPR; ins; Insulin A chain; Insulin B chain; IRDN; MODY10; Preproinsulin; Proinsulin; Proinsulin precursor; anti-INS antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
• Concentration: 300 mug/mL (varies by lot)
• Sequence Length: 108

• Applicable Applications for anti-INS antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:200-1:1000
• Immunogen: Recombinant protein corresponding to Mouse insulin
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded mouse pancreas using Insulin Polyclonal Antibody at dilution of 1:300.)

Related Product Information for anti-INS antibody

Insulin is a peptide hormone, produced by beta cells of the pancreas, and is central to regulating carbohydrate and fat metabolism in the body. It participates in glucose utilization, protein synthesis and in the formation and storage of neutral lipids. Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to secretion. A- and B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide. Defects in insulin results in type 1 diabetes mellitus. Insulin may also exist 36 kDa form corresponding to the hexameric insulin form.

Product Categories/Family for anti-INS antibody

Cancer; Cardiovascular; Metabolism; Neuroscience; Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 117606345
• NCBI GeneID: 16333
• NCBI Accession #: NP_032412.3
• NCBI GenBank Nucleotide #: NM_008386.4
• UniProt Accession #: P01325; Q545I7; Q9D907
• Molecular Weight: 12,160 Da
• NCBI Official Full Name: insulin-1 preproprotein
• NCBI Official Synonym Full Names: insulin I
• NCBI Official Symbol: Ins1
• NCBI Official Synonym Symbols: Ins-1; Ins2-rs1
• NCBI Protein Information: insulin-1
• UniProt Protein Name: Insulin-1
• Protein Family: Insulin
• UniProt Gene Name: Ins1
• UniProt Synonym Gene Names: Ins-1

NCBI Description

This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. [provided by RefSeq, Aug 2015]

Uniprot Description

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.