Western Blot (WB)
(Anti- IP3 receptor antibody, MBS177520, Western blottingAll lanes: Anti IP3 receptor (MBS177520) at 0.5ug/mlWB: Recombinant Human IP3 receptor Protein 0.5ngPredicted bind size: 45KDObserved bind size: 45KD )
Rabbit Inositol 1,4,5-trisphosphate receptor type 1 Polyclonal Antibody | anti-ITPR1 antibody
Anti-IP3 receptor Antibody
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human, Mouse, Rat
Western Blot (WB)
(Anti- IP3 receptor antibody, MBS177520, Western blottingAll lanes: Anti IP3 receptor (MBS177520) at 0.5ug/mlWB: Recombinant Human IP3 receptor Protein 0.5ngPredicted bind size: 45KDObserved bind size: 45KD )
Western Blot (WB)
(Anti- IP3 receptor antibody, MBS177520, Western blottingAll lanes: Anti IP3 receptor (MBS177520) at 0.5ug/mlWB: Recombinant Human IP3 receptor Protein 0.5ngPredicted bind size: 45KDObserved bind size: 45KD )
Western Blot (WB)
(Anti- IP3 receptor antibody, MBS177520, Western blottingAll lanes: Anti IP3 receptor (MBS177520) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Rat Liver Tissue Lysate at 50ugLane 3: HELA Whole Cell Lysate at 40ugLane 4: HEPG2 Whole Cell Lysate at 40ugPredicted bind size: 314KDObserved bind size: 314KD )
Western Blot (WB)
(Anti- IP3 receptor antibody, MBS177520, Western blottingAll lanes: Anti IP3 receptor (MBS177520) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Rat Liver Tissue Lysate at 50ugLane 3: HELA Whole Cell Lysate at 40ugLane 4: HEPG2 Whole Cell Lysate at 40ugPredicted bind size: 314KDObserved bind size: 314KD )
Immunohistochemistry (IHC)
(Anti- IP3 receptor antibody, MBS177520,IHC(P)IHC(P): Mouse Brain Tissue )
Immunohistochemistry (IHC)
(Anti- IP3 receptor antibody, MBS177520,IHC(P)IHC(P): Mouse Brain Tissue )
Immunohistochemistry (IHC)
(Anti- IP3 receptor antibody, MBS177520,IHC(P)IHC(P): Rat Brain Tissue )
Immunohistochemistry (IHC)
(Anti- IP3 receptor antibody, MBS177520,IHC(P)IHC(P): Rat Brain Tissue )
Immunohistochemistry (IHC)
(Anti- IP3 receptor antibody, MBS177520,IHC(P)IHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- IP3 receptor antibody, MBS177520,IHC(P)IHC(P): Human Lung Cancer Tissue )
Background: Inositol 1,4,5-trisphosphate receptor type 1, also known as IP3R or IP3R1, is a protein that in humans is encoded by the ITPR1 gene. It is mapped to 3p26.1. The product of the ITPR1 gene is predominantly enriched in cerebellar Purkinje cells but is also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. The ITPR1 gene encodes the inositol 1,4,5-triphosphate(IP3) receptor, an intracellular IP3-gated calcium channel that modulates intracellular calcium signaling. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
Uniprot Description
IP3R1: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaMKII, eventually leading to the activation of downstream apoptosis pathways. Part of a cGMP kinase signaling complex that includes alpha-actin, calponin H1, phospholamban, PKG1 and IP3R1. Widely expressed. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA prevents the ligand-induced opening of the calcium channels. Belongs to the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family. Eight alternatively spliced isoforms have been described.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 3p26.1
Cellular Component: endoplasmic reticulum membrane; membrane; sarcoplasmic reticulum; endoplasmic reticulum; postsynaptic density; nucleolus; integral to membrane; nuclear inner membrane; platelet dense granule membrane; calcineurin complex
Molecular Function: protein binding; calcium ion transmembrane transporter activity; calcium channel inhibitor activity; intracellular ligand-gated calcium channel activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity
Biological Process: negative regulation of calcium-mediated signaling; epidermal growth factor receptor signaling pathway; platelet activation; inositol phosphate-mediated signaling; voluntary musculoskeletal movement; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; post-embryonic development; endoplasmic reticulum calcium ion homeostasis; phospholipase C activation; release of sequestered calcium ion into cytosol; calcium ion transport; response to hypoxia; energy reserve metabolic process; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; regulation of insulin secretion
Research Articles on ITPR1
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Product Notes
The ITPR1 itpr1 (Catalog #AAA177520) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-IP3 receptor Antibody reacts with Human, Mouse, Rat. No cross reactivity with other proteins. and may cross-react with other species as described in the data sheet. AAA Biotech's Inositol 1,4,5-trisphosphate receptor type 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC-P). Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human, Rat Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human, Mouse, Rat. Researchers should empirically determine the suitability of the ITPR1 itpr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Inositol 1,4,5-trisphosphate receptor type 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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