SDS-PAGE
(A431 cells were subjected to SDS PAGE followed by western blot with INF2 antibody at dilution of 1:500)
Rabbit anti-Human, Mouse INF2 Polyclonal Antibody | anti-INF2 antibody
INF2 Antibody
IHC: 1:50-1:200
SDS-PAGE
(A431 cells were subjected to SDS PAGE followed by western blot with INF2 antibody at dilution of 1:500)
SDS-PAGE
(A431 cells were subjected to SDS PAGE followed by western blot with INF2 antibody at dilution of 1:500)
Immunohistochemical
(Immunohistochemical of paraffin-embedded human kidney using INF2 antibody at dilution of 1:100 (under 40x lens))
Immunohistochemical
(Immunohistochemical of paraffin-embedded human kidney using INF2 antibody at dilution of 1:100 (under 40x lens))
NCBI and Uniprot Product Information
NCBI Description
This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010]
Uniprot Description
INF2: Severs actin filaments and accelerates their polymerization and depolymerization. Defects in INF2 are the cause of focal segmental glomerulosclerosis type 5 (FSGS5). A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Defects in INF2 are the cause of Charcot-Marie-Tooth disease, dominant intermediate type E (CMTDIE). A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type E is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. Patients additionally manifest focal segmental glomerulonephritis, proteinuria, progression to end- stage renal disease, and a characteristic histologic pattern on renal biopsy. Belongs to the formin homology family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 14q32.33
Cellular Component: perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; nucleus
Molecular Function: Rho GTPase binding; actin binding
Biological Process: regulation of cellular component size; actin cytoskeleton organization and biogenesis
Disease: Focal Segmental Glomerulosclerosis 5; Charcot-marie-tooth Disease, Dominant Intermediate E
Research Articles on INF2
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Product Notes
The INF2 inf2 (Catalog #AAA2517228) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The INF2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's INF2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). WB: 1:1000-1:10000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the INF2 inf2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "INF2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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