Western Blot (WB)
(GUCA2B Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the GUCA2B antibody detected the GUCA2B protein (arrow).)
Rabbit anti-Human GUCA2B Polyclonal Antibody | anti-GUCA2B antibody
GUCA2B Antibody (C-term)
Western Blot (WB)
(GUCA2B Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the GUCA2B antibody detected the GUCA2B protein (arrow).)
Western Blot (WB)
(GUCA2B Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the GUCA2B antibody detected the GUCA2B protein (arrow).)
homologs of the bacterial heat-stable enterotoxins (e.g., the E.
coli ST toxin; STa), are endogenous activators of the guanylate
cyclase-2C receptor (GUCY2C; MIM 601330), which synthesizes cyclic
GMP (cGMP), a key component of several intracellular signal
transduction pathways.
Guo, H.F., et al. Zhonghua Xin Xue Guan Bing Za Zhi 35(3):233-236(2007)
Sindic, A., et al. Kidney Int. 67(4):1420-1427(2005)
Maake, C., et al. Histochem. Cell Biol. 119(1):69-76(2003)
Sindice, A., et al. J. Biol. Chem. 277(20):17758-17764(2002)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the guanylin family, and is expressed in the stomach and intestine. This protein functions as an endogenous ligand for the guanylate cyclase-C receptor and stimulates an increase in cyclic GMP, a key component of several intracellular signal transduction pathways. It maybe involved in salt and water secretion into the intestinal lumen as well as the renal tubules, and thus regulate electrolyte homeostasis in these tissues. [provided by RefSeq, Oct 2011]
Uniprot Description
GUCA2B: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. Belongs to the guanylin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1p34-p33
Molecular Function: calcium sensitive guanylate cyclase activator activity
Biological Process: cGMP biosynthetic process; positive regulation of guanylate cyclase activity; negative regulation of blood pressure; body fluid secretion; excretion
Research Articles on GUCA2B
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Product Notes
The GUCA2B guca2b (Catalog #AAA9214634) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 69-97. The GUCA2B Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GUCA2B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the GUCA2B guca2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GUCA2B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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