Western Blot (WB)
(Western Blot analysis of IMPA1 in Human cerebrum tissue lysate using IMPA1 Rabbit pAb at dilution 1/360)
Rabbit IMPA1 Polyclonal Antibody | anti-IMPA1 antibody
IMPA1 Rabbit pAb
IHC-P: 1:25-1:100
Western Blot (WB)
(Western Blot analysis of IMPA1 in Human cerebrum tissue lysate using IMPA1 Rabbit pAb at dilution 1/360)
Western Blot (WB)
(Western Blot analysis of IMPA1 in Human cerebrum tissue lysate using IMPA1 Rabbit pAb at dilution 1/360)
Immunohistochemistry (IHC)
(Immunohistochemistry of IMPA1 in paraffin-embedded Human liver cancer tissue using IMPA1 Rabbit pAb at dilution 1/25. Predicted cell location: Cytoplasm and Nucleus)
Immunohistochemistry (IHC)
(Immunohistochemistry of IMPA1 in paraffin-embedded Human liver cancer tissue using IMPA1 Rabbit pAb at dilution 1/25. Predicted cell location: Cytoplasm and Nucleus)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
Uniprot Description
IMPA1: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Belongs to the inositol monophosphatase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.94; Phosphatase (non-protein); Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.25
Chromosomal Location of Human Ortholog: 8q21.13-q21.3
Cellular Component: cytoplasm; cytosol
Molecular Function: identical protein binding; protein homodimerization activity; manganese ion binding; inositol-1(or 4)-monophosphatase activity; magnesium ion binding; lithium ion binding
Biological Process: inositol phosphate metabolic process; phosphoinositide phosphorylation; inositol biosynthetic process; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; signal transduction; phosphate metabolic process
Research Articles on IMPA1
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Product Notes
The IMPA1 impa1 (Catalog #AAA4759163) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IMPA1 Rabbit pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IMPA1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:500-1:2000 IHC-P: 1:25-1:100. Researchers should empirically determine the suitability of the IMPA1 impa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IMPA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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