Mouse anti-Human ILP2 Polyclonal Antibody | anti-BIRC8 antibody

ILP2 (Baculoviral IAP Repeat-containing Protein 8, Inhibitor of Apoptosis-like Protein 2, IAP-like Protein 2, ILP-2, Testis-specific Inhibitor of Apoptosis, BIRC8)

Cat. Num. AAA6008726

• Gene Names: BIRC8; ILP2; ILP-2; hILP2
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: ILP2; Polyclonal Antibody; ILP2 (Baculoviral IAP Repeat-containing Protein 8; Inhibitor of Apoptosis-like Protein 2; IAP-like Protein 2; ILP-2; Testis-specific Inhibitor of Apoptosis; BIRC8); Anti -ILP2 (Baculoviral IAP Repeat-containing Protein 8; anti-BIRC8 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human BIRC8.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MTGYEARLITFGTWMYSVNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHAKWYPGCKYLLEEKGHEYINNIHLTRSLEGALVQTTKKTPSLTKRISDTIFPNPMLQEAIRMGFDFKDVKKIMEERIQTSGSNYKTLGVLVADLVSAQKDTTENELNQTSLQREISPEEPLRRLQEEKLCKICMDRHIAVVFIPCGHLVTCKQCAEAVDRCPMCSMVIDFKQRVFMS

• Applicable Applications for anti-BIRC8 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human BIRC8, aa1-236 (AAH39318.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of BIRC8 expression in transfected 293T cell line by BIRC8 polyclonal antibody. Lane 1: BIRC8 transfected lysate (25.96kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-BIRC8 antibody

ILP-2 (for IAP-like protein-2) is a novel member of in the IAP (Inhibitor of Apoptosis) protein family. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibit apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9.

Product Categories/Family for anti-BIRC8 antibody

Antibodies; Abs to Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 15042064
• NCBI GeneID: 112401
• UniProt Accession #: Q96P09; Q6IPY1; Q96RW5
• Molecular Weight: 27,089 Da
• NCBI Official Full Name: IAP-like protein 2
• NCBI Official Synonym Full Names: baculoviral IAP repeat containing 8
• NCBI Official Symbol: BIRC8
• NCBI Official Synonym Symbols: ILP2; ILP-2; hILP2
• NCBI Protein Information: baculoviral IAP repeat-containing protein 8; IAP-like protein 2; baculoviral IAP repeat-containing 8; inhibitor of apoptosis-like protein 2; testis-specific inhibitor of apoptosis
• UniProt Protein Name: Baculoviral IAP repeat-containing protein 8
• Protein Family: Baculoviral IAP repeat-containing protein
• UniProt Gene Name: BIRC8
• UniProt Synonym Gene Names: ILP2; IAP-like protein 2; ILP-2
• UniProt Entry Name: BIRC8_HUMAN

Uniprot Description

BIRC8: Protects against apoptosis mediated by BAX. Belongs to the IAP family.

Protein type: Ubiquitin conjugating system; Apoptosis

Chromosomal Location of Human Ortholog: -

Cellular Component: perinuclear region of cytoplasm; spindle microtubule; cytoplasm; cytosol; nucleus

Molecular Function: protease binding; zinc ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity

Biological Process: neuron apoptosis; protein ubiquitination; negative regulation of neuron apoptosis; negative regulation of apoptosis