Rabbit ILP-interacting Protein Polyclonal Antibody | anti-STRADB antibody

ILP-interacting Protein (ILPIP, Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region Candidate 2, ALSCR2, CALS-21, ILP-interacting Protein ILPIPA, ILPIPA, Likely Ortholog of Mouse Polyploidy Associated Protein Kinase, PAPK, PRO1038)

Cat. Num. AAA610213

• Gene Names: STRADB; PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038; MGC102916
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: ILP-interacting Protein; Polyclonal Antibody; ILP-interacting Protein (ILPIP; Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region Candidate 2; ALSCR2; CALS-21; ILP-interacting Protein ILPIPA; ILPIPA; Likely Ortholog of Mouse Polyploidy Associated Protein Kinase; PAPK; PRO1038); Anti -ILP-interacting Protein (ILPIP; anti-STRADB antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody is specific for PAPK. Species Crossreactivity: Mu
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.

• Applicable Applications for anti-STRADB antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Residues 399-418 (SPWSELEFQFPDDKDPVWEF) of the mouse PAPK protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-STRADB antibody

A novel protein kinase, polyploidy-associated protein kinase (PAPK) is a new member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival. Activation of a death signal transduction pathway may result in the stimulation of the PAPK promoter, which leads to increased PAPK expression and provides a negative feedback signal that prevents cell death.

Product Categories/Family for anti-STRADB antibody

Antibodies; Abs to Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 20384952
• NCBI GeneID: 55437
• UniProt Accession #: Q9C0K7; Q5BKY7; Q9P1L0
• Molecular Weight: 47,026 Da
• NCBI Official Full Name: ILP-interacting protein ILPIPA
• NCBI Official Synonym Full Names: STE20-related kinase adaptor beta
• NCBI Official Symbol: STRADB
• NCBI Official Synonym Symbols: PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038; MGC102916
• NCBI Protein Information: STE20-related kinase adapter protein beta; STRAD beta; OTTHUMP00000163729; OTTHUMP00000206592; pseudokinase ALS2CR2; ILP-interacting protein ILPIPA; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein
• UniProt Protein Name: STE20-related kinase adapter protein beta
• Protein Family: STE20-related kinase adapter protein
• UniProt Gene Name: STRADB
• UniProt Synonym Gene Names: ALS2CR2; ILPIP
• UniProt Entry Name: STRAB_HUMAN

NCBI Description

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Uniprot Description

STLK6: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Kinase, protein; STE group; STE20 family; STLK subfamily

Chromosomal Location of Human Ortholog: 2q33.1

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: protein binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: insulin receptor signaling pathway; activation of protein kinase activity; cell morphogenesis; JNK cascade; mitotic cell cycle; protein export from nucleus; cell cycle arrest; protein amino acid phosphorylation