Testing Data
(Fig: Western blot analysis on K562(A) and human skin tissue (B)using anti- IL-7R-alpha polyclonal antibody)
anti-Human IL-7R-alpha Polyclonal Antibody | anti-IL-7R-alpha antibody
IL-7R-alpha (CD127 or CDw127) Antibody
Gene Names
IL7R; ILRA; CD127; IL7RA; CDW127; IL-7R-alpha
Reactivity
Human
Applications
Western Blot, Immunocytochemistry
Purity
Affinity purified
Synonyms
IL-7R-alpha; Polyclonal Antibody; IL-7R-alpha (CD127 or CDw127) Antibody; anti-IL-7R-alpha antibody
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of N-terminal residues of human IL-7R-alpha.
Purity/Purification
Affinity purified
Form/Format
1*TBS (pH7.4), 0.5%BSA, 25% Glycerol.
Sequence Length
459
Applicable Applications for anti-IL-7R-alpha antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes
WB: 1:1,000-5,000
Preservative
0.05% Sodium Azide.
Cellular Localization
Secretion Protein/Cell Membrane
Positive Control
Skin Tissue
Preparation and Storage
Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.
Testing Data
(Fig: Western blot analysis on K562(A) and human skin tissue (B)using anti- IL-7R-alpha polyclonal antibody)
Testing Data
(Fig: Western blot analysis on K562(A) and human skin tissue (B)using anti- IL-7R-alpha polyclonal antibody)
Testing Data #2
Testing Data #2
Related Product Information for anti-IL-7R-alpha antibody
The IL-7 cytokine plays a major role in the in vivo maintenance of polyclonal naive and memory T cells, positively regulating the survival, differentiation and proliferation of thymocyte and peripheral T lymphocyte populations. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor-specific chain and the IL-2 receptor gamma chain common to the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors. Soluble forms of the IL-7 Ralpha have been reported.
References
1. Yu L.-R., Zhu Z., et al. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; J. Proteome Res. 6:4150-4162(2007). 2. Roifman C.M., Zhang J., et al. "A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency."; Blood 96:2803-2807(2000). 3. Gregory S.G., Schmidt S., Seth P., et al. "Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis."; Nat. Genet. 39:1083-1091(2007).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
52; 34; 30; 75kDa
NCBI Official Full Name
interleukin-7 receptor subunit alpha
NCBI Official Synonym Full Names
interleukin 7 receptor
NCBI Official Symbol
IL7R
NCBI Official Synonym Symbols
ILRA; CD127; IL7RA; CDW127; IL-7R-alpha
NCBI Protein Information
interleukin-7 receptor subunit alpha
UniProt Protein Name
Interleukin-7 receptor subunit alpha
UniProt Gene Name
IL7R
UniProt Synonym Gene Names
IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA
NCBI Description
The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]
Uniprot Description
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Research Articles on IL-7R-alpha
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Product Notes
The IL-7R-alpha il7r (Catalog #AAA856855) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The IL-7R-alpha (CD127 or CDw127) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL-7R-alpha can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC). WB: 1:1,000-5,000. Researchers should empirically determine the suitability of the IL-7R-alpha il7r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-7R-alpha, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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