Rabbit IL-31 Polyclonal Antibody | anti-IL31 antibody
RABBIT ANTI HUMAN INTERLEUKIN-31
Gene Names
IL31; IL-31
Applications
ELISA, Western Blot
Synonyms
IL-31; Polyclonal Antibody; RABBIT ANTI HUMAN INTERLEUKIN-31; anti-IL31 antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Form/Format
Purified
Purified IgG - lyophilised
Purified IgG - lyophilised
Concentration
IgG concentration 1.0mg/ml (varies by lot)
Sequence Length
164
Applicable Applications for anti-IL31 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
ELISA: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml;
Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml
Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml
Reconstitution
Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended.
Immunogen
Recombinant human IL-31.
Buffer Solution
Buffer Solution
Antiserum Preparation
Antisera to human IL-31 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Target Species
Human
Preparation and Storage
Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
Shelf Life: 12 months from date of reconstitution.
Related Product Information for anti-IL31 antibody
Rabbit anti Human Interleukin-31 antibody recognizes human IL-31 (interleukin-31), a 141 amino acid T-cell derived cytokine and member of the IL-6 cytokine family, which shares homology with oncostatin M, cardiotrophin-1 and LIF (leukaemia inhibitory factor)..IL-31 is preferentially produced by type 2 helper T cells (Th2) and signals through binding to the IL-31 receptor consisting of IL-31 receptor A (IL-31RA/GPL) and oncostatin M receptor B, activators of STAT1, STAT3 and STAT5. IL-31 is an important mediator of T cell mediated immune response and is particularly linked with diseases of the skin, including dermatitis and pruritic atopic skin inflammation, and is also implicated in bronchial inflammation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18,205 Da
NCBI Official Full Name
interleukin-31
NCBI Official Synonym Full Names
interleukin 31
NCBI Official Symbol
IL31
NCBI Official Synonym Symbols
IL-31
NCBI Protein Information
interleukin-31
UniProt Protein Name
Interleukin-31
Protein Family
UniProt Gene Name
IL31
UniProt Synonym Gene Names
IL-31
UniProt Entry Name
IL31_HUMAN
NCBI Description
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
Uniprot Description
IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.
Protein type: Secreted; Secreted, signal peptide; Cytokine
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: extracellular space
Molecular Function: cytokine activity
Biological Process: immune system process
Research Articles on IL31
Similar Products
Product Notes
The IL31 il31 (Catalog #AAA222765) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's IL-31 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). ELISA: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml; Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml. Researchers should empirically determine the suitability of the IL31 il31 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-31, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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