Rabbit anti-Human IGFBP1 Polyclonal Antibody | anti-IGFBP1 antibody

Anti-IGFBP1 antibody

Cat. Num. AAA175710

• Gene Names: IGFBP1; AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
• Reactivity: Human
• Applications: Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: IGFBP1; Polyclonal Antibody; Anti-IGFBP1 antibody; Insulin-like growth factor-binding protein 1(IBP-1/IGF-binding protein 1/IGFBP-1); insulin-like growth factor binding protein 1; AFBP antibody; Alpha pregnancy associated endometrial globulin antibody; Amniotic fluid binding protein antibody; Binding protein 25 antibody; Binding protein 26 antibody; Binding protein 28 antibody; Growth hormone independent binding protein antibody; hIGFBP 1 antibody; hIGFBP1 antibody; IBP 1 antibody; IBP-1 antibody; IBP1 antibody; IBP1_HUMAN antibody; IGF binding protein 1 antibody; IGF BP25 antibody; IGF-binding protein 1 antibody; IGFBP 1 antibody; IGFBP-1 antibody; IGFBP1 antibody; Insulin Like Growth Factor Binding Protein 1 antibody; Insulin-like growth factor-binding protein 1 antibody; Placental protein 12 antibody; PP 12 antibody; PP12 antibody; anti-IGFBP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 259

• Applicable Applications for anti-IGFBP1 antibody: Western Blot (WB)
• Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human IGFBP1 (170-190aa KEPCRIELYRVVESLAKAQET).
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti-IGFBP-1 antibody, MBS175710, Western blottingLane 1: SMMC Cell LysateLane 2: MCF-7 Cell Lysate )

Related Product Information for anti-IGFBP1 antibody

Description: Rabbit IgG polyclonal antibody for Insulin-like growth factor-binding protein 1(IGFBP1) detection. Tested with WB in Human.
Background: IGFBP1, Insulin-like growth factor-binding protein 1, also known as placental protein 12(PP12), is a protein that in humans is encoded by the IGFBP1 gene. The IGFBP1 gene has 4 exons and spans 5.9 kb. The IGFBP1gene is localized to 7p13-p12 by in situ hybridization. This gene is a member of the Insulin-like growth factor-binding protein(IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors(IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

NCBI and Uniprot Product Information

• NCBI GI #: 124055
• NCBI GeneID: 3484
• UniProt Accession #: P08833; Q8IYP5; A4D2F4; D3DVL9
• Molecular Weight: 27,904 Da
• NCBI Official Full Name: Insulin-like growth factor-binding protein 1
• NCBI Official Synonym Full Names: insulin-like growth factor binding protein 1
• NCBI Official Symbol: IGFBP1
• NCBI Official Synonym Symbols: AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
• NCBI Protein Information: insulin-like growth factor-binding protein 1; IBP-1; IGFBP-1; binding protein-25; binding protein-26; binding protein-28; placental protein 12; IGF-binding protein 1; amniotic fluid binding protein; growth hormone independent-binding protein; alpha-pregnancy-associated endometrial globulin
• UniProt Protein Name: Insulin-like growth factor-binding protein 1
• Protein Family: Insulin-like growth factor-binding protein
• UniProt Gene Name: IGFBP1
• UniProt Synonym Gene Names: IBP1; IBP-1; IGF-binding protein 1; IGFBP-1; PP12
• UniProt Entry Name: IBP1_HUMAN

NCBI Description

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

Uniprot Description

IGFBP1: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p12.3

Cellular Component: extracellular space; extracellular region

Molecular Function: insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding

Biological Process: cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; regulation of insulin-like growth factor receptor signaling pathway; tissue regeneration; unfolded protein response; insulin receptor signaling pathway; signal transduction; positive regulation of cell growth