Rabbit IFNAR1 Polyclonal Antibody | anti-IFNAR1 antibody

IFNAR1 Antibody

Cat. Num. AAA5316180

• Gene Names: IFNAR1; AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC
• Applications: Western Blot, Immunoprecipitation
• Purity: Immunogen Affinity Chromatography
• Synonyms: IFNAR1; Polyclonal Antibody; IFNAR1 Antibody; Purified Polyclonal IFNAR1 Antibody; Polyclonal IFNAR1 antibody; Anti-IFNAR1 antibody; IFNAR antibody; Interferon alpha/beta receptor 1 antibody; IFN-R-1 antibody; IFN-alpha/beta receptor 1 antibody; Cytokine receptor class-II member 1 antibody; Cytokine receptor family 2 member 1 antibody; CRF2-1 antibody; Type I interferon receptor 1 antibody; anti-IFNAR1 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of IFNAR1 protein
• Purity/Purification: Immunogen Affinity Chromatography
• Form/Format: Supplied in liquid form in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3 with 30% Glycerol and 0.01% Sodium Azide
• Sequence Length: 557

• Applicable Applications for anti-IFNAR1 antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: WB: 1:500-1:1000; IP: 1:10-1:100
• Immunogen: IFNAR1 antibody was raised in Rabbit using a KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human IFNAR1 (pY466) as the immunogen
• Preparation and Storage: Store at 4 degree C for short term storage. For long term, aliquot and store at -20 degree C. Avoid repeat freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of IFNAR1 (pY466) expression in K562 EGF-treated (A) whole cell lysates.)

Related Product Information for anti-IFNAR1 antibody

IFNAR1 is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2.

Product Categories/Family for anti-IFNAR1 antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 46488932
• NCBI GeneID: 3454
• NCBI GenBank Nucleotide #: NP_000620.2
• UniProt Accession #: P17181
• NCBI Official Full Name: interferon alpha/beta receptor 1
• NCBI Official Synonym Full Names: interferon alpha and beta receptor subunit 1
• NCBI Official Symbol: IFNAR1
• NCBI Official Synonym Symbols: AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC
• NCBI Protein Information: interferon alpha/beta receptor 1
• UniProt Protein Name: Interferon alpha/beta receptor 1
• Protein Family: Interferon alpha/beta receptor
• UniProt Gene Name: IFNAR1
• UniProt Synonym Gene Names: IFNAR; IFN-R-1; IFN-alpha/beta receptor 1; CRF2-1
• UniProt Entry Name: INAR1_HUMAN

NCBI Description

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

Uniprot Description

IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; interferon receptor activity; interferon-alpha/beta receptor activity

Biological Process: positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; T cell activation; response to virus; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-1 beta secretion; JAK-STAT cascade; interferon type I biosynthetic process; defense response to virus