Rabbit anti-Human IFIT2 Polyclonal Antibody | anti-IFIT2 antibody

IFIT2 (Interferon-induced Protein with Tetratricopeptide Repeats 2, IFIT-2, ISG-54 K, Interferon-induced 54 kDa Protein, IFI-54K, P54, CIG-42, G10P2, IFI54, ISG54)

Cat. Num. AAA6007471

• Gene Names: IFIT2; P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; GARG-39; IFI-54K; ISG-54K; ISG-54 K
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: IFIT2; Polyclonal Antibody; IFIT2 (Interferon-induced Protein with Tetratricopeptide Repeats 2; IFIT-2; ISG-54 K; Interferon-induced 54 kDa Protein; IFI-54K; P54; CIG-42; G10P2; IFI54; ISG54); Anti -IFIT2 (Interferon-induced Protein with Tetratricopeptide Repeats 2; anti-IFIT2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human IFIT2.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MSENNKNSLESSLRQLKCHFTWNLMEGENSLDDFEDKVFYRTEFQNREFKATMCNLLAYLKHLKGQNEAALECLRKAEELIQQEHADQAEIRSLVTWGNYAWVYYHMGRLSDVQIYVDKVRHVCEKFSSPYRIESPELDCEEGWTRLKCGGNQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWPPSQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYRAKVFQVMNLRENGMYGKRKLLELIGHAVAHLKKADEANDNLFRVCSILASLHALADQYEEAEYYFQKEFSKELTPVAKQLLHLRYGNFQLYQMKCEDKAIHHFIEGVKINQKSREKEKMKDKLQKIAKMRLSKNGADSEALHVLAFLQELNEKMQQADEDSERGLESGSLIPSASSWNGEWRIEMWCPLGYC

• Applicable Applications for anti-IFIT2 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human IFIT2, aa1-484 (NP_001538.3).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of IFIT2 expression in transfected 293T cell line by IFIT2 polyclonal antibody. Lane 1: IFIT2 transfected lysate (56.2kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-IFIT2 antibody

IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.

Product Categories/Family for anti-IFIT2 antibody

Antibodies; Abs to Interferon

NCBI and Uniprot Product Information

• NCBI GI #: 153082755
• NCBI GeneID: 3433
• NCBI Accession #: NP_001538.4
• NCBI GenBank Nucleotide #: NM_001547.4
• UniProt Accession #: P09913; Q5T767
• Molecular Weight: 54,632 Da
• NCBI Official Full Name: interferon-induced protein with tetratricopeptide repeats 2
• NCBI Official Synonym Full Names: interferon-induced protein with tetratricopeptide repeats 2
• NCBI Official Symbol: IFIT2
• NCBI Official Synonym Symbols: P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; GARG-39; IFI-54K; ISG-54K; ISG-54 K
• NCBI Protein Information: interferon-induced protein with tetratricopeptide repeats 2; interferon-induced protein 54; interferon-induced 54 kDa protein; Interferon, alpha-inducible protein (MW 54kD)
• UniProt Protein Name: Interferon-induced protein with tetratricopeptide repeats 2
• Protein Family: Interferon-induced protein with tetratricopeptide repeats
• UniProt Gene Name: IFIT2
• UniProt Synonym Gene Names: CIG-42; G10P2; IFI54; ISG54; IFIT-2; IFI-54K; P54
• UniProt Entry Name: IFIT2_HUMAN

Uniprot Description

IFIT2: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Can promote apoptosis. Belongs to the IFIT family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: endoplasmic reticulum; cytoplasm; cytosol

Molecular Function: protein binding

Biological Process: apoptotic mitochondrial changes; positive regulation of apoptosis; cytokine and chemokine mediated signaling pathway; response to virus; negative regulation of protein binding; defense response to virus