Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using IER3 Polyclonal Antibody at dilution of 1:35(×200))
Rabbit anti-Human, Mouse IER3 Polyclonal Antibody | anti-IER3 antibody
IER3 Polyclonal Antibody
ELISA: 1:5000-1:10000
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using IER3 Polyclonal Antibody at dilution of 1:35(×200))
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using IER3 Polyclonal Antibody at dilution of 1:35(×200))
NCBI and Uniprot Product Information
NCBI Description
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]
Uniprot Description
IEX-1: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. Belongs to the IER3 family.
Protein type: Membrane protein, integral; Apoptosis
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: integral to membrane; nucleus
Molecular Function: protein binding
Biological Process: regulation of DNA repair; anatomical structure morphogenesis; response to protozoan; DNA damage response, signal transduction resulting in induction of apoptosis; apoptosis; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of systemic arterial blood pressure; regulation of nucleocytoplasmic transport; negative regulation of inflammatory response; positive regulation of protein catabolic process; negative regulation of glycolysis; negative regulation of apoptosis
Research Articles on IER3
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Product Notes
The IER3 ier3 (Catalog #AAA2561640) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IER3 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IER3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA). IHC: 1:25-1:100 ELISA: 1:5000-1:10000. Researchers should empirically determine the suitability of the IER3 ier3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IER3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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