Rabbit anti-Human IDE Polyclonal Antibody | anti-IDE antibody

IDE Antibody, Biotin conjugated

Cat. Num. AAA7048423

• Gene Names: IDE; INSULYSIN
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G purified
• Synonyms: IDE; Polyclonal Antibody; IDE Antibody; Biotin conjugated; Insulin-degrading enzyme; Abeta-degrading protease; Insulin protease; Insulinase; Insulysin; anti-IDE antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 464

• Applicable Applications for anti-IDE antibody: ELISA (EIA)
• Immunogen: Recombinant human Insulin-degrading enzyme protein (501-800AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugation: Biotin
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27266 / sc-130784
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-IDE antibody

Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.

NCBI and Uniprot Product Information

• NCBI GI #: 260099676
• NCBI GeneID: 3416
• NCBI Accession #: NP_001159418.1
• NCBI GenBank Nucleotide #: NM_001165946.1
• UniProt Accession #: P14735; Q5T5N2; B2R721; B7ZAU2; D3DR35
• Molecular Weight: 54,240 Da
• NCBI Official Full Name: insulin-degrading enzyme isoform 2
• NCBI Official Synonym Full Names: insulin degrading enzyme
• NCBI Official Symbol: IDE
• NCBI Official Synonym Symbols: INSULYSIN
• NCBI Protein Information: insulin-degrading enzyme
• UniProt Protein Name: Insulin-degrading enzyme
• Protein Family: IgM protease
• UniProt Gene Name: IDE
• UniProt Synonym Gene Names: Insulinase
• UniProt Entry Name: IDE_HUMAN

NCBI Description

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

Uniprot Description

IDE: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. Belongs to the peptidase M16 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; EC 3.4.24.56; Nuclear receptor co-regulator; Protease

Chromosomal Location of Human Ortholog: 10q23-q25

Cellular Component: cell surface; cytoplasm; cytosol; extracellular space; mitochondrion; nucleoplasm; nucleus; peroxisomal matrix; peroxisome

Molecular Function: ATP binding; glycoprotein binding; insulin binding; metalloendopeptidase activity; peptide binding; protein binding; protein homodimerization activity; receptor binding; ubiquitin binding; zinc ion binding

Biological Process: beta-amyloid metabolic process; determination of adult life span; positive regulation of protein oligomerization; protein homooligomerization; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process