Western Blot (WB)
(Western Blot analysis of extracts of various cell lines, using ICOSLG antibody.)
Rabbit ICOSLG Polyclonal Antibody | anti-ICOSLG antibody
ICOSLG Polyclonal Antibody
Gene Names
ICOSLG; B7h; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
ICOSLG; Polyclonal Antibody; ICOSLG Polyclonal Antibody; ICOS ligand; B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD275; B7H2; B7RP1; ICOSL; KIAA0653; anti-ICOSLG antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
ICOSLG polyclonal antibody detects endogenous levels of ICOSLG protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
302
Applicable Applications for anti-ICOSLG antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IHC: 1:50-1:200
Immunogen
Recombinant full length Human ICOSLG.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot analysis of extracts of various cell lines, using ICOSLG antibody.)
Western Blot (WB)
(Western Blot analysis of extracts of various cell lines, using ICOSLG antibody.)
Related Product Information for anti-ICOSLG antibody
T cell costimulatory molecule, inducible costimulator (ICOS)/B7-related protein-1 (B7RP-1, B7-H2, GL50, ICOS-L) is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. B7RP-1 interactions play an essential role in T cell dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. B7RP-1 protein is present in myeloid leukocytes and by Northern blot there are 2.4, 3.0 and 7.0 kb transcripts in brain, heart, kidney and liver, with lower expression in colon and thymus and a 1.1 kb transcript in leukocytes. Tumor necrosis factor å (TNFå), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4) enhance B7RP-1 expression. LPS induced up regulation of B7RP-1 is dependent on the MyD88 dependent signaling pathway.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
~ 50-70kDa
NCBI Official Full Name
ICOS ligand
NCBI Official Synonym Full Names
inducible T cell costimulator ligand
NCBI Official Symbol
ICOSLG
NCBI Official Synonym Symbols
B7h; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
NCBI Protein Information
ICOS ligand
UniProt Protein Name
ICOS ligand
Protein Family
UniProt Gene Name
ICOSLG
UniProt Synonym Gene Names
B7H2; B7RP1; ICOSL; KIAA0653; B7-H2; B7RP-1
Uniprot Description
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function ().
Research Articles on ICOSLG
Similar Products
Product Notes
The ICOSLG icoslg (Catalog #AAA3011937) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ICOSLG Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ICOSLG can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the ICOSLG icoslg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ICOSLG, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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