Goat HWP1 Polyclonal Antibody | anti-HWP1 antibody

Goat anti-HWP1 (Candida) Antibody

Cat. Num. AAA422902

• Reactivity: Expected from sequence similarity: Candida albicans SC5314
• Applications: ELISA
• Purity: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Synonyms: HWP1; Polyclonal Antibody; Goat anti-HWP1 (Candida) Antibody; ECE2; ECE2 antibody; HWP1 antibody; HWP1 (Candida); anti-HWP1 antibody

• Host: Goat
• Reactivity: Expected from sequence similarity: Candida albicans SC5314
• Clonality: Polyclonal
• Purity/Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Form/Format: Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: 100ug specific antibody in 200ul (varies by lot)
• Sequence: QPSIPAGETSPAVPK
• Sequence Length: 634

• Applicable Applications for anti-HWP1 antibody: Peptide ELISA (EIA)
• Application Notes: Peptide ELISA: Antibody detection limit dilution 1: 128000.; Western Blot: Not yet tested. At this stage we are dependent on researchers in the field for further characterization of this product. Therefore we cannot recommend an optimal concentration and the antibody is an aspiring product.
• Immunogen: Peptide with sequence C-QPSIPAGETSPAVPK, from the internal region of the protein sequence according to XP_712998.1.
• Epitope: Internal region
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 68486282
• NCBI GeneID: 3645386
• NCBI Accession #: XP_712998.1
• NCBI GenBank Nucleotide #: XM_707905.1
• NCBI Official Full Name: hyphal-specific cell wall protein aka ECE2
• NCBI Official Symbol: HWP1
• NCBI Protein Information: hyphal-specific cell wall protein; aka ECE2; C terminus similar to that of HWP99 and RBT1; similar to S. cerevisiae MUC1 (YIR019C) cell surface flocculin
• UniProt Protein Name: Hyphal wall protein 1
• Protein Family: Hyphal wall protein
• UniProt Gene Name: HWP1
• UniProt Synonym Gene Names: ECE2
• UniProt Entry Name: HWP1_CANAL

Uniprot Description

Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence factors and host inflammatory responses when protective immunity is absent.