Rabbit anti-Human HTR2B Polyclonal Antibody | anti-HTR2B antibody

HTR2B Polyclonal Antibody

Cat. Num. AAA2528174

• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purification
• Synonyms: HTR2B; Polyclonal Antibody; HTR2B Polyclonal Antibody; 5-HT2B; 5-HT(2B); anti-HTR2B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Concentration: 0.2mg/mL (varies by lot)
• Sequence Length: 481

• Applicable Applications for anti-HTR2B antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:100-1:300
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using HTR2B Polyclonal Antibody at dilution 1:60)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using HTR2B Polyclonal Antibody at dilution 1:60)

Related Product Information for anti-HTR2B antibody

Background: This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.

NCBI and Uniprot Product Information

• NCBI GI #: 649119383
• UniProt Accession #: P41595
• NCBI Official Full Name: HTR2B, partial

Uniprot Description

5-HT(2B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q36.3-q37.1

Cellular Component: cytoplasm; dendrite; integral to plasma membrane; plasma membrane

Molecular Function: drug binding; G-protein alpha-subunit binding; GTPase activator activity; neurotransmitter receptor activity; serotonin binding; serotonin receptor activity

Biological Process: calcium-mediated signaling; cellular calcium ion homeostasis; cGMP biosynthetic process; embryonic morphogenesis; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); heart morphogenesis; intestine smooth muscle contraction; negative regulation of apoptosis; negative regulation of autophagy; neural crest cell differentiation; neural crest cell migration; phosphoinositide 3-kinase cascade; phospholipase C activation; phosphorylation; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of cytokine secretion; positive regulation of endothelial cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAP kinase activity; positive regulation of nitric-oxide synthase activity; positive regulation of phosphatidylinositol biosynthetic process; protein kinase C activation; regulation of behavior; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; synaptic transmission; vasoconstriction