Western Blot (WB)
(Anti- 5HT2B Receptor Picoband antibody, MBS177864, Western blottingAll lanes: Anti 5HT2B Receptor (MBS177864) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: U87 Whole Cell Lysate at 40ugPredicted bind size: 54KDObserved bind size: 54KD )
anti-Human, Rat 5HT2B Receptor Polyclonal Antibody | anti-HTR2B antibody
Anti-5HT2B Receptor Antibody
Western Blot (WB)
(Anti- 5HT2B Receptor Picoband antibody, MBS177864, Western blottingAll lanes: Anti 5HT2B Receptor (MBS177864) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: U87 Whole Cell Lysate at 40ugPredicted bind size: 54KDObserved bind size: 54KD )
Western Blot (WB)
(Anti- 5HT2B Receptor Picoband antibody, MBS177864, Western blottingAll lanes: Anti 5HT2B Receptor (MBS177864) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: U87 Whole Cell Lysate at 40ugPredicted bind size: 54KDObserved bind size: 54KD )
Background: 5HT2B Receptor is known as HTR2B. This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Uniprot Description
5-HT(2B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q36.3-q37.1
Cellular Component: cell junction; cell soma; cytoplasm; dendrite; integral to plasma membrane; plasma membrane; synapse
Molecular Function: drug binding; G-protein alpha-subunit binding; GTPase activator activity; serotonin binding; serotonin receptor activity
Biological Process: behavior; calcium-mediated signaling; cellular calcium ion homeostasis; cGMP biosynthetic process; embryonic morphogenesis; G-protein coupled receptor internalization; G-protein coupled receptor protein signaling pathway; heart morphogenesis; inositol phosphate metabolic process; intestine smooth muscle contraction; negative regulation of apoptosis; negative regulation of autophagy; neural crest cell differentiation; neural crest cell migration; phosphoinositide 3-kinase cascade; phospholipase C activation; phosphorylation; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of cytokine secretion; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAP kinase activity; positive regulation of nitric-oxide synthase activity; positive regulation of phosphatidylinositol biosynthetic process; protein kinase C activation; regulation of behavior; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; vasoconstriction
Research Articles on HTR2B
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Product Notes
The HTR2B htr2b (Catalog #AAA177864) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-5HT2B Receptor Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's 5HT2B Receptor can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the HTR2B htr2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "5HT2B Receptor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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