Rabbit HTR2B Polyclonal Antibody | anti-HTR2B antibody

HTR2B Antibody

Cat. Num. AAA9414168

• Gene Names: HTR2B; 5-HT2B; 5-HT(2B)
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: HTR2B; Polyclonal Antibody; HTR2B Antibody; 5-HT2B; 5-HT(2B); anti-HTR2B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total HTR2B protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 481

• Applicable Applications for anti-HTR2B antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:50 - 1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human HTR2B.
• Target Name: HTR2B
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using HTR2B antibody.)

Related Product Information for anti-HTR2B antibody

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.

Product Categories/Family for anti-HTR2B antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 222080049
• NCBI GeneID: 3357
• NCBI Accession #: NP_000858.3
• NCBI GenBank Nucleotide #: NM_000867.4
• UniProt Accession #: P41595; Q53TI1; Q62221; Q6P523; B2R9D5; AAB31827
• Molecular Weight: 54,298 Da
• NCBI Official Full Name: 5-hydroxytryptamine receptor 2B
• NCBI Official Synonym Full Names: 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
• NCBI Official Symbol: HTR2B
• NCBI Official Synonym Symbols: 5-HT2B; 5-HT(2B)
• NCBI Protein Information: 5-hydroxytryptamine receptor 2B
• UniProt Protein Name: 5-hydroxytryptamine receptor 2B
• UniProt Gene Name: HTR2B
• UniProt Synonym Gene Names: 5-HT-2B; 5-HT2B
• UniProt Entry Name: 5HT2B_HUMAN

NCBI Description

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]

Uniprot Description

5-HT(2B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q36.3-q37.1

Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; synapse; cell junction

Molecular Function: serotonin binding; serotonin receptor activity; G-protein alpha-subunit binding; drug binding

Biological Process: heart morphogenesis; cGMP biosynthetic process; negative regulation of autophagy; phosphoinositide 3-kinase cascade; intestine smooth muscle contraction; behavior; positive regulation of MAP kinase activity; positive regulation of cell proliferation; protein kinase C activation; neural crest cell differentiation; embryonic morphogenesis; neural crest cell migration; serotonin receptor signaling pathway; regulation of behavior; response to drug; positive regulation of cytokine production; vasoconstriction; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of nitric-oxide synthase activity; calcium-mediated signaling; positive regulation of phosphatidylinositol biosynthetic process; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; G-protein coupled receptor internalization; phospholipase C activation; positive regulation of cell division; release of sequestered calcium ion into cytosol; positive regulation of endothelial cell proliferation; phosphorylation; negative regulation of apoptosis; positive regulation of cytokine secretion