Rabbit HTR1E / 5-HT1E Receptor Polyclonal Antibody | anti-HTR1E antibody

Rabbit Polyclonal to Human HTR1E / 5-HT1E Receptor

Cat. Num. AAA244106

• Gene Names: HTR1E; 5-HT1E
• Reactivity: Gibbon, Bovine, Chimpanzee, Chicken, Guinea pig, Gorilla, Horse, Human, Monkey, Orangutan; Predicted Reactivity: Bat (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: HTR1E / 5-HT1E Receptor; Polyclonal Antibody; Rabbit Polyclonal to Human HTR1E / 5-HT1E Receptor; Anti-HTR1E / 5-HT1E Receptor Antibody (Cytoplasmic Domain) IHC-plus; HTR1E; 5-HT1E; 5-HT1e receptor; 5-HT-1E; 5HT1E Receptor; HT1e receptor; S31; Serotonin 5-HT-1e receptor; Serotonin 1e receptor; Serotonin receptor 1E; Human HTR1E; 5-HT1E Receptor; anti-HTR1E antibody

• Host: Rabbit
• Reactivity: Gibbon, Bovine, Chimpanzee, Chicken, Guinea pig, Gorilla, Horse, Human, Monkey, Orangutan; Predicted Reactivity: Bat (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human 5HT1E Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except HTR1F (65%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 365

• Applicable Applications for anti-HTR1E antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (10 ug/ml); Usage: Antigen retrieval requires Proteinase K treatment.
• Target Species: Human
• Immunogen Description: Synthetic 17 amino acid peptide from 3rd cytoplasmic domain of human 5HT1E Receptor.
• Immunogen Type: Synthetic peptide
• Immunogen: HTR1E / 5-HT1E Receptor antibody was raised against synthetic 17 amino acid peptide from 3rd cytoplasmic domain of human 5HT1E Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Elephant, Panda, Bovine, Horse, Guinea pig, Turkey, Sparrow, Chicken, Lizard (100%); Bat, Opossum (94%); Stickleback, Zebrafish (88%).
• Antigen Modification: Cytoplasmic Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-5HT1E Receptor antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-5HT1E Receptor antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-HTR1E antibody

5HT1E, a Serotonin Receptor, is not well studied. It is classified as an 5-HT1-like receptor because of its ligand-binding and effector-coupling characteristics. The human 5-HT1E receptor has been studied in an African green monkey kidney cell line, in which it modulated cAMP levels upon binding serotonin. Lack of structural variants in the human gene indicate a highly conserved protein.

Product Categories/Family for anti-HTR1E antibody

Family: GPCR; Subfamily: Serotonin

NCBI and Uniprot Product Information

• NCBI GI #: 4504537
• NCBI GeneID: 3354
• NCBI Accession #: NP_000856.1
• NCBI GenBank Nucleotide #: NM_000865.2
• UniProt Accession #: P28566; Q9P1Y1; E1P503
• Molecular Weight: 41,682 Da
• NCBI Official Full Name: 5-hydroxytryptamine receptor 1E
• NCBI Official Synonym Full Names: 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
• NCBI Official Symbol: HTR1E
• NCBI Official Synonym Symbols: 5-HT1E
• NCBI Protein Information: 5-hydroxytryptamine receptor 1E; S31; 5-HT-1E; serotonin receptor 1E
• UniProt Protein Name: 5-hydroxytryptamine receptor 1E
• Protein Family: 5-hydroxytryptamine receptor
• UniProt Gene Name: HTR1E
• UniProt Synonym Gene Names: 5-HT-1E; 5-HT1E
• UniProt Entry Name: 5HT1E_HUMAN

Uniprot Description

5-HT(1E): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 6q14-q15

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; serotonin binding; serotonin receptor activity

Biological Process: synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; negative regulation of cAMP metabolic process; G-protein signaling, adenylate cyclase inhibiting pathway; serotonin receptor signaling pathway