Immunohistochemistry (IHC)
(Immunohistochemistry analysis of human prostate tissue stained with HSP90, pAb at 10µg/ml.)
Rabbit HSP90 Polyclonal Antibody | anti-Heat shock protein 90 antibody
HSP90 polyclonal antibody
Gene Names
HSP90AA1; EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4; HEL-S-65p
Reactivity
Human, Mouse, Rat, Rabbit
Applications
Immunohistochemistry, Western Blot
Purity
Protein A affinity purified.
Synonyms
HSP90; Polyclonal Antibody; HSP90 polyclonal antibody; anti-Heat shock protein 90 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat, Rabbit
Clonality
Polyclonal
Specificity
Recognizes human, mouse, rat and rabbit HSP90. Detects a band of ~90kDa by Western blot.
Purity/Purification
Protein A affinity purified.
Form/Format
Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Sequence Length
732
Applicable Applications for anti-Heat shock protein 90 antibody
Immunohistochemistry (IHC) (PS), Western Blot (WB)
Application Notes
Western Blot (1:1,000, Colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Detects a band of ~90kDa by Western blot.
Suggested dilutions/conditions may not be available for all applications.
Detects a band of ~90kDa by Western blot.
Immunogen
Synthetic peptide corresponding to aa 250-325 of human Hsp90.
Preparation and Storage
Long term storage: -20 degree C
Avoid freeze/thaw cycles.
Avoid freeze/thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of human prostate tissue stained with HSP90, pAb at 10µg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of human prostate tissue stained with HSP90, pAb at 10µg/ml.)
Related Product Information for anti-Heat shock protein 90 antibody
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.
Product Categories/Family for anti-Heat shock protein 90 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
98,161 Da
NCBI Official Full Name
Heat shock protein HSP 90-alpha
NCBI Official Synonym Full Names
heat shock protein 90kDa alpha family class A member 1
NCBI Official Symbol
HSP90AA1
NCBI Official Synonym Symbols
EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4; HEL-S-65p
NCBI Protein Information
heat shock protein HSP 90-alpha
UniProt Protein Name
Heat shock protein HSP 90-alpha
Protein Family
UniProt Gene Name
HSP90AA1
UniProt Synonym Gene Names
HSP90A; HSPC1; HSPCA; HSP 86; HSP86; LAP-2; LPS-associated protein 2
UniProt Entry Name
HS90A_HUMAN
NCBI Description
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Description
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11274138, PubMed:11276205, PubMed:15577939, PubMed:15937123, PubMed:27353360).
Research Articles on Heat shock protein 90
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Product Notes
The Heat shock protein 90 hsp90aa1 (Catalog #AAA565270) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HSP90 polyclonal antibody reacts with Human, Mouse, Rat, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's HSP90 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) (PS), Western Blot (WB). Western Blot (1:1,000, Colorimetric) Suggested dilutions/conditions may not be available for all applications. Detects a band of ~90kDa by Western blot. Researchers should empirically determine the suitability of the Heat shock protein 90 hsp90aa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HSP90, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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