Rabbit anti-Human HSD11B2 Polyclonal Antibody | anti-HSD11B2 antibody

HSD11B2 (HSD11K, Corticosteroid 11-beta-dehydrogenase Isozyme 2, 11-beta-hydroxysteroid Dehydrogenase Type 2, 11-beta-hydroxysteroid Dehydrogenase Type II, NAD-dependent 11-beta-hydroxysteroid Dehydrogenase) (Biotin)

Cat. Num. AAA6381696

• Gene Names: HSD11B2; AME; AME1; HSD2; HSD11K; SDR9C3
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HSD11B2; Polyclonal Antibody; HSD11B2 (HSD11K; Corticosteroid 11-beta-dehydrogenase Isozyme 2; 11-beta-hydroxysteroid Dehydrogenase Type 2; 11-beta-hydroxysteroid Dehydrogenase Type II; NAD-dependent 11-beta-hydroxysteroid Dehydrogenase) (Biotin); anti-HSD11B2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human HSD11B2.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Sequence Length: 1939

• Applicable Applications for anti-HSD11B2 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human HSD11B2, aa1-405 (AAH64536.1).
• Immunogen Sequence: MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFTHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HSD11B2 rabbit polyclonal antibody. Western Blot analysis of HSD11B2 expression in human placenta.)

Western Blot (WB)

(Western Blot analysis of HSD11B2 expression in transfected 293T cell line by HSD11B2 polyclonal antibody. Lane 1: HSD11B2 transfected lysate (44.1kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-HSD11B2 antibody

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

Product Categories/Family for anti-HSD11B2 antibody

Antibodies; Enzymes; Dehydrogenase

NCBI and Uniprot Product Information

• NCBI GI #: 40352985
• NCBI GeneID: 3291
• NCBI Official Full Name: Homo sapiens hydroxysteroid (11-beta) dehydrogenase 2, mRNA
• NCBI Official Synonym Full Names: hydroxysteroid 11-beta dehydrogenase 2
• NCBI Official Symbol: HSD11B2
• NCBI Official Synonym Symbols: AME; AME1; HSD2; HSD11K; SDR9C3
• NCBI Protein Information: corticosteroid 11-beta-dehydrogenase isozyme 2
• Protein Family: Corticosteroid 11-beta-dehydrogenase isozyme

NCBI Description

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]