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Western Blot (WB) (HSD11B2 rabbit polyclonal antibody. Western Blot analysis of HSD11B2 expression in human placenta.)

Rabbit anti-Human HSD11B2 Polyclonal Antibody | anti-HSD11B2 antibody

HSD11B2 (HSD11K, Corticosteroid 11-beta-dehydrogenase Isozyme 2, 11-beta-hydroxysteroid Dehydrogenase Type 2, 11-beta-hydroxysteroid Dehydrogenase Type II, NAD-dependent 11-beta-hydroxysteroid Dehydrogenase) APC

Gene Names
HSD11B2; AME; AME1; HSD2; HSD11K; SDR9C3
Reactivity
Human
Applications
Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
HSD11B2; Polyclonal Antibody; HSD11B2 (HSD11K; Corticosteroid 11-beta-dehydrogenase Isozyme 2; 11-beta-hydroxysteroid Dehydrogenase Type 2; 11-beta-hydroxysteroid Dehydrogenase Type II; NAD-dependent 11-beta-hydroxysteroid Dehydrogenase) APC; anti-HSD11B2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human HSD11B2.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Sequence Length
1939
Applicable Applications for anti-HSD11B2 antibody
Western Blot (WB)
Application Notes
Applications are based on unconjugated antibody.
Immunogen
Full length human HSD11B2, aa1-405 (AAH64536.1).
Immunogen Sequence
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFTHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
Conjugate
APC
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(HSD11B2 rabbit polyclonal antibody. Western Blot analysis of HSD11B2 expression in human placenta.)

Western Blot (WB) (HSD11B2 rabbit polyclonal antibody. Western Blot analysis of HSD11B2 expression in human placenta.)

Western Blot (WB)

(Western Blot analysis of HSD11B2 expression in transfected 293T cell line by HSD11B2 polyclonal antibody. Lane 1: HSD11B2 transfected lysate (44.1kD). Lane 2: Non-transfected lysate.)

Western Blot (WB) (Western Blot analysis of HSD11B2 expression in transfected 293T cell line by HSD11B2 polyclonal antibody. Lane 1: HSD11B2 transfected lysate (44.1kD). Lane 2: Non-transfected lysate.)
Related Product Information for anti-HSD11B2 antibody
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
Product Categories/Family for anti-HSD11B2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Official Full Name
Homo sapiens hydroxysteroid (11-beta) dehydrogenase 2, mRNA
NCBI Official Synonym Full Names
hydroxysteroid 11-beta dehydrogenase 2
NCBI Official Symbol
HSD11B2
NCBI Official Synonym Symbols
AME; AME1; HSD2; HSD11K; SDR9C3
NCBI Protein Information
corticosteroid 11-beta-dehydrogenase isozyme 2

NCBI Description

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]

Research Articles on HSD11B2

Similar Products

Product Notes

The HSD11B2 (Catalog #AAA6381695) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HSD11B2 (HSD11K, Corticosteroid 11-beta-dehydrogenase Isozyme 2, 11-beta-hydroxysteroid Dehydrogenase Type 2, 11-beta-hydroxysteroid Dehydrogenase Type II, NAD-dependent 11-beta-hydroxysteroid Dehydrogenase) APC reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HSD11B2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the HSD11B2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HSD11B2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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