Rabbit HRH3 Polyclonal Antibody | anti-HRH3 antibody

HRH3 Polyclonal Antibody

Cat. Num. AAA2526025

• Gene Names: HRH3; HH3R; GPCR97
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: HRH3; Polyclonal Antibody; HRH3 Polyclonal Antibody; HH3R; GPCR97; anti-HRH3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.3mg/mL (varies by lot)
• Sequence Length: 445

• Applicable Applications for anti-HRH3 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using HRH3 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using HRH3 Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-HRH3 antibody

Background/Introduction: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffinlike cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system.

NCBI and Uniprot Product Information

• NCBI GI #: 17367264
• NCBI GeneID: 11255
• Molecular Weight: 45,607 Da
• NCBI Official Full Name: Histamine H3 receptor
• NCBI Official Synonym Full Names: histamine receptor H3
• NCBI Official Symbol: HRH3
• NCBI Official Synonym Symbols: HH3R; GPCR97
• NCBI Protein Information: histamine H3 receptor; G protein-coupled receptor 97; G-protein coupled receptor 97; H3R
• UniProt Protein Name: Histamine H3 receptor
• Protein Family: Histamine H3 receptor
• UniProt Gene Name: HRH3
• UniProt Synonym Gene Names: GPCR97; H3R; HH3R
• UniProt Entry Name: HRH3_HUMAN

NCBI Description

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]

Uniprot Description

H3R: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization. Belongs to the G-protein coupled receptor 1 family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane; myelin sheath

Molecular Function: drug binding; histamine receptor activity

Biological Process: negative regulation of glutamate secretion; eating behavior; neurotransmitter secretion; drinking behavior; negative regulation of gamma-aminobutyric acid secretion; negative regulation of adenylate cyclase activity; learning; regulation of norepinephrine secretion; response to organic cyclic substance; memory; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of serotonin secretion; elevation of cytosolic calcium ion concentration; brain development; negative regulation of blood pressure; positive regulation of epithelial cell proliferation