Rabbit CAP1 Polyclonal Antibody | anti-CAP1 antibody

CAP1 Rabbit Polyclonal

Cat. Num. AAA767478

• Gene Names: Park7; Dj1; CAP1; DJ-1; SP22
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: CAP1; Polyclonal Antibody; CAP1 Rabbit Polyclonal; anti-CAP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 189

• Applicable Applications for anti-CAP1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
• Immunogen: CAP, adenylate cyclase-associated protein 1 (yeast)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using MBS767478 (CAP1 Antibody) at dilution of 1:50)

Testing Data

()

Western Blot (WB)

(mouse skin tissue were subjected to SDS PAGE followed by western blot with MBS767478 (CAP1 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 3250916
• NCBI GeneID: 117287
• UniProt Accession #: O88767
• Molecular Weight: 19,974 Da
• NCBI Official Full Name: CAP1
• NCBI Official Synonym Full Names: Parkinsonism associated deglycase
• NCBI Official Symbol: Park7
• NCBI Official Synonym Symbols: Dj1; CAP1; DJ-1; SP22
• NCBI Protein Information: protein deglycase DJ-1
• UniProt Protein Name: Protein deglycase DJ-1
• Protein Family: CAP1-binding-protein
• UniProt Gene Name: Park7
• UniProt Synonym Gene Names: Protein CAP1
• UniProt Entry Name: PARK7_RAT

NCBI Description

displays a specific localization pattern to the anterior-ventral surface of the equatorial segment; may play a role in sperm-egg interactions and fertilization [RGD, Feb 2006]

Uniprot Description

DJ-1: associated with autosomal recessive early onset parkinsonism. Involved in the oxidative stress response. Three cysteines in DJ-1 may be oxidized to cysteine sulphonic acid in the cellular response to H2O2. Loss of DJ-1 function may lead to neurodegeneration.

Protein type: Transcription regulation; EC 3.4.-.-; Nuclear receptor co-regulator; Tumor suppressor

Cellular Component: axon; chromatin; cytoplasm; cytosol; endoplasmic reticulum; lipid raft; mitochondrial intermembrane space; mitochondrial matrix; mitochondrial respiratory chain complex I; mitochondrion; neuron projection; nucleus; plasma membrane; PML body

Molecular Function: androgen receptor binding; copper ion binding; cytokine binding; double-stranded DNA binding; enzyme binding; glyoxalase III activity; identical protein binding; kinase binding; mercury ion binding; mRNA binding; oxidoreductase activity, acting on peroxide as acceptor; peptidase activity; peroxiredoxin activity; protein binding; protein homodimerization activity; receptor binding; single-stranded DNA binding; superoxide dismutase copper chaperone activity; transcription coactivator activity; transcription factor binding

Biological Process: adult locomotory behavior; autophagy; detoxification of copper ion; detoxification of mercury ion; dopamine uptake; enzyme active site formation via L-cysteine sulfinic acid; fertilization; glycolate biosynthetic process; hydrogen peroxide metabolic process; inflammatory response; lactate biosynthetic process; membrane depolarization; membrane hyperpolarization; methylglyoxal catabolic process to D-lactate; mitochondrion organization and biogenesis; negative regulation of apoptosis; negative regulation of neuron apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein amino acid phosphorylation; negative regulation of protein binding; negative regulation of protein catabolic process; negative regulation of protein export from nucleus; negative regulation of protein kinase activity; negative regulation of protein sumoylation; negative regulation of protein ubiquitination; negative regulation of ubiquitin-protein ligase activity; positive regulation of interleukin-8 production; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein deglycosylation; protein stabilization; proteolysis; regulation of inflammatory response; regulation of mitochondrial membrane potential; regulation of neuron apoptosis; regulation of TRAIL receptor biosynthetic process; regulation of transcription from RNA polymerase II promoter; response to drug; response to hydrogen peroxide; response to oxidative stress; single fertilization; synaptic transmission, dopaminergic