Goat anti-Human HRH1 Polyclonal Antibody | anti-HRH1 antibody

HRH1, CT (Histamine H1 receptor, H1R, HH1R)

Cat. Num. AAA646134

• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: HRH1; Polyclonal Antibody; CT (Histamine H1 receptor; H1R; HH1R); Anti -HRH1; anti-HRH1 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human HRH1. Species sequence homology: Canine, mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in TBS, 0.02% sodium azide, pH 7.3, 0.5% BSA.

• Applicable Applications for anti-HRH1 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:32,000; Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml
• Immunogen: Synthetic peptide corresponding to human HRH1 at C-terminal (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Small Intestine, Smooth Muscle (formalin-fixed, paraffin-embedded) stained with HRH1 antibody at 2.5ug/ml followed by biotinylated anti-goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-HRH1 antibody

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Product Categories/Family for anti-HRH1 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 146186871
• NCBI GeneID: 281231
• UniProt Accession #: P30546
• Molecular Weight: 55,957 Da
• NCBI Official Full Name: HRH1 protein
• NCBI Official Synonym Full Names: histamine receptor H1<
• NCBI Official Symbol: HRH1
• NCBI Protein Information: histamine H1 receptor; H1R; HH1R
• UniProt Protein Name: Histamine H1 receptor
• Protein Family: Histamine H1 receptor
• UniProt Gene Name: HRH1
• UniProt Synonym Gene Names: H1R; HH1R
• UniProt Entry Name: HRH1_BOVIN

Uniprot Description

Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Tissue specificity: Brain, lung, small intestine, uterus, adrenal medulla and spleen.

Post-translational modification: Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation

By similarity.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.