Rabbit HOXB13 Polyclonal Antibody | anti-HOXB13 antibody

HOXB13, CT (HOXB13, Homeobox protein Hox-B13) (Azide free) (HRP)

Cat. Num. AAA6307807

• Gene Names: HOXB13; PSGD
• Reactivity: Human; Predicted: Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HOXB13; Polyclonal Antibody; CT (HOXB13; Homeobox protein Hox-B13) (Azide free) (HRP); Homeobox protein Hox-B13; anti-HOXB13 antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-HOXB13 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: HOXB13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-251 amino acids from the C-terminal region of human HOXB13.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HOXB13 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the HOXB13 antibody detected the HOXB13 protein (arrow).)

Related Product Information for anti-HOXB13 antibody

This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region.

Product Categories/Family for anti-HOXB13 antibody

Antibodies; Transcription Factors; Zinc; Ring; Homeobox

References

McMullin, R.P., et al. Proc. Natl. Acad. Sci. U.S.A. 107(1):98-103(2010). Kim, Y.R., et al. Mol. Cancer 9, 124 (2010): Norris, J.D., et al. Mol. Cell 36(3):405-416(2009). Goetz, M.P., et al. Clin. Cancer Res. 14(18):5864-5868(2008). Rodriguez, B.A., et al. Carcinogenesis 29(7):1459-1465(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 62865866
• NCBI GeneID: 10481
• NCBI Accession #: NP_006352.2
• NCBI GenBank Nucleotide #: NM_006361.5
• UniProt Accession #: Q92826; Q96QM4; Q99810; B2R878
• Molecular Weight: 30,676 Da
• NCBI Official Full Name: homeobox protein Hox-B13
• NCBI Official Synonym Full Names: homeobox B13
• NCBI Official Symbol: HOXB13
• NCBI Official Synonym Symbols: PSGD
• NCBI Protein Information: homeobox protein Hox-B13
• UniProt Protein Name: Homeobox protein Hox-B13
• Protein Family: Homeobox protein
• UniProt Gene Name: HOXB13
• UniProt Entry Name: HXB13_HUMAN

NCBI Description

This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]

Uniprot Description

HOXB13: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function: sequence-specific DNA binding

Biological Process: epidermis development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of growth; response to wounding; response to testosterone stimulus; angiogenesis