Rabbit anti-Human HNRPLL Polyclonal Antibody | anti-HNRNPLL antibody

HNRPLL, NT (HNRPLL, SRRF, Heterogeneous nuclear ribonucleoprotein L-like, Stromal RNA-regulating factor)

Cat. Num. AAA644223

• Gene Names: HNRNPLL; SRRF; HNRPLL
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: HNRPLL; Polyclonal Antibody; NT (HNRPLL; SRRF; Heterogeneous nuclear ribonucleoprotein L-like; Stromal RNA-regulating factor); Anti -HNRPLL; anti-HNRNPLL antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-HNRNPLL antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: HNRPLL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-162 amino acids from the N-terminal region of human HNRPLL.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HNRPLL Antibody (N-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the HNRPLL antibody detected the HNRPLL protein (arrow).)

Related Product Information for anti-HNRNPLL antibody

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).

Product Categories/Family for anti-HNRNPLL antibody

Antibodies; Abs to Nuclear Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 20149709
• NCBI GeneID: 92906
• NCBI Accession #: NP_612403.2
• NCBI GenBank Nucleotide #: NM_138394.3
• UniProt Accession #: Q8WVV9; Q53T80; Q5JB51; Q659B9; Q8IVH5; Q8IVH6; Q96HR5
• Molecular Weight: 60,083 Da
• NCBI Official Full Name: heterogeneous nuclear ribonucleoprotein L-like isoform 1
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein L-like
• NCBI Official Symbol: HNRNPLL
• NCBI Official Synonym Symbols: SRRF; HNRPLL
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein L-like; stromal RNA regulating factor; stromal RNA-regulating factor
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein L-like
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: HNRNPLL
• UniProt Synonym Gene Names: HNRPLL; SRRF; hnRNPLL
• UniProt Entry Name: HNRLL_HUMAN

NCBI Description

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]

Uniprot Description

HNRPLL: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. Interacts with HNRNPL. Up-regulated in stimulated T-cells. Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 2p22.1

Cellular Component: membrane; nucleus; ribonucleoprotein complex

Molecular Function: mRNA binding; protein binding; nucleotide binding

Biological Process: mRNA processing; positive regulation of RNA splicing