Rabbit anti-Human HNRNPH2 Polyclonal Antibody | anti-HNRNPH2 antibody

HNRNPH2, CT (HNRNPH2, FTP3, HNRPH2, Heterogeneous nuclear ribonucleoprotein H2, FTP-3, Heterogeneous nuclear ribonucleoprotein H') (FITC)

Cat. Num. AAA6307509

• Gene Names: HNRNPH2; FTP3; HNRPH'; HNRPH2; hnRNPH'
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HNRNPH2; Polyclonal Antibody; CT (HNRNPH2; FTP3; HNRPH2; Heterogeneous nuclear ribonucleoprotein H2; FTP-3; Heterogeneous nuclear ribonucleoprotein H') (FITC); Heterogeneous nuclear ribonucleoprotein H'; anti-HNRNPH2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-HNRNPH2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: HNRNPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-340 amino acids from the C-terminal region of human HNRNPH2.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HNRNPH2 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the HNRNPH2 antibody detected the HNRNPH2 protein (arrow).)

Related Product Information for anti-HNRNPH2 antibody

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein.

Product Categories/Family for anti-HNRNPH2 antibody

Antibodies; Nuclear Proteins

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Maggi, L.B. Jr., et al. Mol. Cell. Biol. 28(23):7050-7065(2008). Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008). Olsen, J.V., et al. Cell 127(3):635-648(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 74099697
• NCBI GeneID: 3188
• NCBI Accession #: NP_001027565.1; NP_062543.1
• NCBI GenBank Nucleotide #: NM_001032393.2
• UniProt Accession #: P55795; Q9HHA7; A1L400
• Molecular Weight: 49,264 Da
• NCBI Official Full Name: heterogeneous nuclear ribonucleoprotein H2
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein H2 (H')
• NCBI Official Symbol: HNRNPH2
• NCBI Official Synonym Symbols: FTP3; HNRPH'; HNRPH2; hnRNPH'
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein H2; FTP-3; hnRNP H'; hnRNP H2; heterogeneous nuclear ribonucleoprotein H-prime
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein H2
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: HNRNPH2
• UniProt Synonym Gene Names: FTP3; HNRPH2; hnRNP H2; hnRNP H'
• UniProt Entry Name: HNRH2_HUMAN

NCBI Description

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011]

Uniprot Description

hnRNP H2: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).

Protein type: RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: nucleoplasm; membrane; nucleus; ribonucleoprotein complex

Molecular Function: RNA binding; nucleotide binding

Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression