Rabbit HNRNPH2 Polyclonal Antibody | anti-HNRNPH2 antibody

Anti-HNRNPH2 Antibody

Cat. Num. AAA415666

• Gene Names: HNRNPH2; FTP3; HNRPH'; HNRPH2; hnRNPH'
• Reactivity: Human. Predicted: Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: HNRNPH2; Polyclonal Antibody; Anti-HNRNPH2 Antibody; anti-HNRNPH2 antibody

• Host: Rabbit
• Reactivity: Human. Predicted: Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 1867

• Applicable Applications for anti-HNRNPH2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: ELISA titer: 1:20,000-1:80,000; Western blot analysis: 1:1,000-1:2,000; Immunohistochemistry: 1:100-1:500; Optimal dilutions/concentrations should be determined by the end user.
• Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
• Immunogen: Rabbit polyclonal HNRNPH2 (1) antibody was raised against a recombinated human HNRNPH2 protein 37-302aa (BC130345).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Related Product Information for anti-HNRNPH2 antibody

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. This gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011]

References

(1) Stark,M., Bram,E.E., Akerman,M., et al. Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance. J. Biol. Chem. 286 (5), 3741-3754 (2011).

NCBI and Uniprot Product Information

• NCBI GI #: 120660029
• NCBI GeneID: 3188
• Molecular Weight: 49,264 Da
• NCBI Official Full Name: Homo sapiens heterogeneous nuclear ribonucleoprotein H2 (H'), mRNA
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein H2 (H')
• NCBI Official Symbol: HNRNPH2
• NCBI Official Synonym Symbols: FTP3; HNRPH'; HNRPH2; hnRNPH'
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein H2; FTP-3; heterogeneous nuclear ribonucleoprotein H-prime; hnRNP H'; hnRNP H2
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein H2
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: HNRNPH2
• UniProt Entry Name: HNRH2_HUMAN

NCBI Description

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011]

Uniprot Description

hnRNP H2: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).

Protein type: RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: nucleoplasm; membrane; nucleus; ribonucleoprotein complex

Molecular Function: RNA binding; nucleotide binding

Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression