Western Blot (WB)
(Western blot analysis of MDA-MB231 cell line lysates (35ug/lane) using H6098-68B. HLA-E (arrow) was detected using the purified Pab.)
Rabbit anti-Human HLA Class 1 Antigen E Polyclonal Antibody | anti-HLAE antibody
HLA Class 1 Antigen E (HLA Class I Histocompatibility Antigen alpha Chain E, HLAE, HLA-E, HLA-6.2, EA1.2, EA2.1, Major Histocompatibility Complex Class I E, MHC Class I Antigen E, QA1) (Biotin)
ELISA: 1:1,000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of MDA-MB231 cell line lysates (35ug/lane) using H6098-68B. HLA-E (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of MDA-MB231 cell line lysates (35ug/lane) using H6098-68B. HLA-E (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of HLA-E (arrow) of 293 cell lysates (2ug/lane) using H6098-68B either nontransfected (Lane 1) or transiently transfected (Lane 2) with the HLA-E gene.)
Western Blot (WB)
(Western blot analysis of HLA-E (arrow) of 293 cell lysates (2ug/lane) using H6098-68B either nontransfected (Lane 1) or transiently transfected (Lane 2) with the HLA-E gene.)
NCBI and Uniprot Product Information
NCBI Description
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Uniprot Description
HLA-E: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. Belongs to the MHC class I family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: Golgi membrane; phagocytic vesicle membrane; cell surface; early endosome membrane; plasma membrane; MHC class I protein complex
Molecular Function: peptide antigen binding; MHC class I protein binding; beta-2-microglobulin binding; receptor binding
Biological Process: regulation of immune response; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; positive regulation of natural killer cell mediated immunity; regulation of natural killer cell mediated immunity; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; innate immune response; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; protection from natural killer cell mediated cytotoxicity
Research Articles on HLAE
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Product Notes
The HLAE hla-e (Catalog #AAA6480922) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HLA Class 1 Antigen E (HLA Class I Histocompatibility Antigen alpha Chain E, HLAE, HLA-E, HLA-6.2, EA1.2, EA2.1, Major Histocompatibility Complex Class I E, MHC Class I Antigen E, QA1) (Biotin) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HLA Class 1 Antigen E can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:100-1:500 ELISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the HLAE hla-e for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HLA Class 1 Antigen E, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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