Rabbit HIPK1 Polyclonal Antibody | anti-HIPK1 antibody

HIPK1 Polyclonal Antibody

Cat. Num. AAA2528919

• Gene Names: HIPK1; Myak; Nbak2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: HIPK1; Polyclonal Antibody; HIPK1 Polyclonal Antibody; Myak; Nbak2; anti-HIPK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.7mg/mL (varies by lot)
• Sequence Length: 816

• Applicable Applications for anti-HIPK1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:100
• Immunogen: Synthetic peptide of human HIPK1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using HIPK1 Polyclonal Antibody at dilution 1:30)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using HIPK1 Polyclonal Antibody at dilution 1:30)

Related Product Information for anti-HIPK1 antibody

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 38201644
• NCBI GeneID: 204851
• NCBI Accession #: NP_852003.1
• NCBI GenBank Nucleotide #: NM_181358.2
• Molecular Weight: 87,302 Da
• NCBI Official Full Name: homeodomain-interacting protein kinase 1 isoform 4
• NCBI Official Synonym Full Names: homeodomain interacting protein kinase 1
• NCBI Official Symbol: HIPK1
• NCBI Official Synonym Symbols: Myak; Nbak2
• NCBI Protein Information: homeodomain-interacting protein kinase 1; homeodomain interacting protein kinase 1-like protein; nuclear body associated kinase 2b; nuclear body-associated kinase 2
• UniProt Protein Name: Homeodomain-interacting protein kinase 1
• UniProt Gene Name: HIPK1
• UniProt Synonym Gene Names: KIAA0630; MYAK; NBAK2
• UniProt Entry Name: HIPK1_HUMAN

NCBI Description

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

HIPK1: homeodomain interacting protein kinase 1 is a CMGC kinase of the DYRK family. May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Expression elevated in many breast cancer cell lines. Null mice are resistant to carcinogens. Binds the p53 tumor suppressor. 4 alternatively spliced isoforms of the human protein have been described.

Protein type: Protein kinase, CMGC; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; DYRK family; HIPK subfamily

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: PML body; cytoplasm; nuclear speck; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: anterior/posterior pattern formation; neuron differentiation; smoothened signaling pathway; positive regulation of angiogenesis; eye development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; embryonic retina morphogenesis in camera-type eye; positive regulation of cell proliferation; embryonic camera-type eye morphogenesis; protein amino acid phosphorylation; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis