Goat anti-Human Heterochromatin Protein 1, beta Polyclonal Antibody | anti-Su(var)205 antibody

Heterochromatin Protein 1, beta (HP1-beta, Chromobox Homolog 1, CBX1, Heterochromatin Protein p25 beta, HP1Hs-beta, M31, Modifier 1 Protein, MOD1, p25beta)

Cat. Num. AAA622871

• Gene Names: Su(var)205; CBX5; CG8409; dHP-1a; dHP1; DmelCG8409; DmHP-1; DmHP1; E(var)29; E(var)29A; FBgn0003607; H3; HP-1; hp1; Hp1; HP1; HP1-VS; hp1a; Hp1a; HP1a; HP1A; HP1alpha; Su(var); Su(var)2-05; Su(var)2-5; Su(Var)2-5; Su(var)2-501; su(var)205; SU(VAR)205; Su(var)29A; Su(
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: Heterochromatin Protein 1; beta; Polyclonal Antibody; beta (HP1-beta; Chromobox Homolog 1; CBX1; Heterochromatin Protein p25 beta; HP1Hs-beta; M31; Modifier 1 Protein; MOD1; p25beta); Anti -Heterochromatin Protein 1; anti-Su(var)205 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CBX1 at ~25kD. Species sequence homology: mouse, rat, canine.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-Su(var)205 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Immunohistochemistry and Western Blot.; Dilution: ELISA: 1:32,000; Immunohistochemistry (paraffin): 2-3ug/ml; Western Blot: 0.3-1.0ug/ml; Optimal dilutions to be determined by the researcher
• Immunogen: Synthetic peptide, C-QSQKTAHETDKSE, from the internal region of human CBX1.
• Positive Control: Lysates of A431, HeLa and HepG2
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 monthsat -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

(H2034-51I(2.5ug/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.)

Related Product Information for anti-Su(var)205 antibody

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Product Categories/Family for anti-Su(var)205 antibody

Antibodies; Abs to Chromatin Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 1170337
• NCBI GeneID: 34119
• UniProt Accession #: P05205; Q9VLR6; A4V0F1; B6UVR4; B6UVS1; B6UVS2; B6UVS3; B6UVT2; B6UVT6; B6UVT7
• Molecular Weight: 23,185 Da
• NCBI Official Full Name: Heterochromatin protein 1
• NCBI Official Synonym Full Names: Suppressor of variegation 205
• NCBI Official Symbol: Su(var)205
• NCBI Official Synonym Symbols: CBX5; CG8409; dHP-1a; dHP1; DmelCG8409; DmHP-1; DmHP1; E(var)29; E(var)29A; FBgn0003607; H3; HP-1; hp1; Hp1; HP1; HP1-VS; hp1a; Hp1a; HP1a; HP1A; HP1alpha; Su(var); Su(var)2-05; Su(var)2-5; Su(Var)2-5; Su(var)2-501; su(var)205; SU(VAR)205; Su(var)29A; Su(
• NCBI Protein Information: CG8409 gene product from transcript CG8409-RA; C1A9-nuclear-antigen; CG8409-PA; CG8409-PB; Su(var)2-5; Su(var)205-PA; Su(var)205-PB; heterochromatic protein; heterochromatic protein 1a; heterochromatin protein 1; heterochromatin protein 1A; heterochromatin protein-1; heterochromatin-binding protein; heterochromatin-protein-1; histone protein 1; suppressor of variegation 205
• UniProt Protein Name: Heterochromatin protein 1
• UniProt Gene Name: Su(var)205
• UniProt Synonym Gene Names: HP1; HP1
• UniProt Entry Name: HP1_DROME

Uniprot Description

Function: Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.

Subunit structure: Homodimer; probably associates with Su(var)3-9. Interacts with Mcm10. Interacts (via chromoshadow domain) with piwi (via N-terminal region). Ref.8 Ref.9 Ref.10 Ref.11

Subcellular location: Nucleus.

Sequence similarities: Contains 2 chromo domains.