Related Product Information for anti-HESX1 antibody
Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation.
Product Categories/Family for anti-HESX1 antibody
NCBI Description
This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. [provided by RefSeq, Jul 2008]
Uniprot Description
HESX1: Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation. Defects in HESX1 are a cause of septooptic dysplasia (SOD); also known as de Morsier syndrome. SOD is a rare autosomal recessive disease. SOD is characterized by optic nerve hypoplasia, absence of the corpus callosum and hypoplasia of the pituitary gland with panhypopopituitarism. Defects in HESX1 are a cause of growth hormone deficiency with pituitary anomalies (GHDPA). Defects in HESX1 are the cause of pituitary hormone deficiency combined type 5 (CPHD5). This disorder is manifested by deficiencies in anterior pituitary tropic hormones. week-old embryo. Belongs to the ANF homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component: nucleus
Molecular Function: protein C-terminus binding; protein binding; DNA binding; sequence-specific DNA binding; protein N-terminus binding; chromatin binding
Biological Process: transcription, DNA-dependent; brain development; otic vesicle formation; negative regulation of transcription, DNA-dependent; forebrain morphogenesis; nose development
Disease: Septooptic Dysplasia
Product Notes
The HESX1 hesx1 (Catalog #
AAA644083) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The HESX1 (Homeobox Expressed in ES Cells 1, Homeobox Protein ANF, hAnf, HANF, ANF, CPHD5, MGC138294) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HESX1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the HESX1 hesx1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MSPSLQEGAQ LGENKPSTCS FSIERILGLD QKKDCVPLMK PHRPWADTCS SSGKDGNLCL HVPNPPSGIS FPSVVDHPMP EERASKYENY FSASERLSLK RELSWYRGRR PRTAFTQNQI EVLENVFRVN CYPGIDIRED LAQKLNLEED RIQIWFQNRR AKLKRSHRES QFLMAKKNFN TNLLE.
It is sometimes possible for the material contained within the vial of
"HESX1, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
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aspect of this datasheet at
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