Western Blot (WB)
(Expression analysis of Hes7. Anti-Hes7 antibody (11-8084) was used at 1 µg/ml on 293 lysate.)
Rabbit Hes7 Polyclonal Antibody | anti-Hes7 antibody
Hes7 Polyclonal Antibody
Western Blot (WB)
(Expression analysis of Hes7. Anti-Hes7 antibody (11-8084) was used at 1 µg/ml on 293 lysate.)
Western Blot (WB)
(Expression analysis of Hes7. Anti-Hes7 antibody (11-8084) was used at 1 µg/ml on 293 lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Description
HES7: Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation. Defects in HES7 are the cause of spondylocostal dysostosis type 4 (SCDO4). A rare condition of variable severity characterized by vertebral and costal anomalies. The main feature include dwarfism, vertebral fusion, hemivertebrae, posterior rib fusion, reduced rib number, and other rib malformations.
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: nucleus
Molecular Function: protein dimerization activity; DNA binding; transcription factor binding
Biological Process: somitogenesis; Notch signaling pathway; transcription, DNA-dependent; rhythmic process; mesoderm development; negative regulation of transcription from RNA polymerase II promoter; regulation of somitogenesis; skeletal development
Disease: Spondylocostal Dysostosis 4, Autosomal Recessive
Research Articles on Hes7
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Product Notes
The Hes7 hes7 (Catalog #AAA668050) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Hes7 Polyclonal Antibody reacts with Human (Predicted Reactivity: Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Hes7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 0.5-1 µg/ml. Researchers should empirically determine the suitability of the Hes7 hes7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Hes7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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