S100A2 recombinant protein

S100A2 Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8120060

• Gene Names: S100A2; CAN19; S100L
• Purity: >95% as determined by SDS-PAGE
• Synonyms: S100A2; S100A2 Protein; Human; Recombinant (hFc Tag); Human S100A2 Protein (Fc Tag); CAN19 Protein; S100L Protein; S100 calcium binding protein A2; S100A2 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH7.5. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met2-Pro98

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Glu 20
• Tag: N-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human S100A2 (NP_005969.1)(Met 2-Pro98) was expressed with the fused Fc region of human IgG1 at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for S100A2 recombinant protein

Background: The calcium-binding protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21, and S100 proteins consisting of at least 20 members are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S100A2 was first detected in lung and kidney, and is mainly expressed in a subset of tissues and cells such as breast epithelia and liver. The S100A2 protein is a homodimer that undergoes a conformational change upon binding of calcium, and the active form functions in regulating cell proliferation and differentiation, gene transcription, and p53-dependent growth arrest and apoptosis. Accordingly, this protein is regarded as a putative tumor suppressor, and thus chromosomal rearrangements and reduced expression of S100A2 gene have been implicated in certain carcinomas.

Product Categories/Family for S100A2 recombinant protein

Calcium-binding Proteins and Related Molecules

References

Gimona, M. et al., 1997, J. Cell. Sci. 110: 611-621. Mueller, A. et al., 2005, J. Biol. Chem. 280: 29186-29193. Lapi, E. et al., 2006, Oncogene. 25: 3628-3637. Feng, G. et al., 2001, Cancer. Res. 61: 7999-8004. Gupta, S. et al., 2003, J. Clin. Oncol. 21: 106-112.

NCBI and Uniprot Product Information

• NCBI GI #: 5174661
• NCBI GeneID: 6273
• NCBI Accession #: NP_005969.1
• NCBI GenBank Nucleotide #: NM_005978.3
• UniProt Accession #: P29034; O00266; Q3KRB9; Q5RHS8; Q9BU83
• Molecular Weight: 11,117 Da
• NCBI Official Full Name: protein S100-A2
• NCBI Official Synonym Full Names: S100 calcium binding protein A2
• NCBI Official Symbol: S100A2
• NCBI Official Synonym Symbols: CAN19; S100L
• NCBI Protein Information: protein S100-A2; S100 calcium-binding protein A2
• UniProt Protein Name: Protein S100-A2
• Protein Family: Protein
• UniProt Gene Name: S100A2
• UniProt Synonym Gene Names: S100L
• UniProt Entry Name: S10A2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]

Uniprot Description

S100A2: May act as a modulator against excess calcium accumulation in normal human mammary epithelial cells. May also play a role in suppressing tumor cell growth. Belongs to the S-100 family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 1q21

Molecular Function: identical protein binding; protein binding; calcium ion binding

Biological Process: endothelial cell migration