Western Blot (WB)
Rabbit HES-5 Polyclonal Antibody | anti-HES-5 antibody
Anti-HES-5 Antibody
ELISA: 1:10,000
WB: 1:500 - 1:1000
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Western Blot (WB)
Western Blot (WB)
J. Biol. Chem. 2006. 281 (8), 5106-5119
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]
Uniprot Description
HES5: Transcriptional repressor of genes that require a bHLH protein for their transcription.
Protein type: Transcription regulation; Cell development/differentiation
Chromosomal Location of Human Ortholog: 1p36.32
Cellular Component: nucleoplasm
Molecular Function: protein dimerization activity; double-stranded DNA binding; chromatin binding; transcription factor binding
Biological Process: neural tube development; radial glial cell differentiation in the forebrain; regulation of myelination; positive regulation of transcription, DNA-dependent; positive regulation of smooth muscle cell proliferation; cell maturation; positive regulation of JAK-STAT cascade; auditory receptor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of neurogenesis; astrocyte differentiation; regulation of cell differentiation; positive regulation of cell proliferation; chondrocyte differentiation; protein complex assembly; cell adhesion; oligodendrocyte development; positive regulation of Notch signaling pathway; positive regulation of BMP signaling pathway; Notch signaling pathway; smoothened signaling pathway; camera-type eye development; transcription, DNA-dependent; auditory receptor cell fate determination; myelination in the central nervous system; negative regulation of oligodendrocyte differentiation; negative regulation of neuron differentiation; telencephalon development; glial cell fate commitment; cartilage development; negative regulation of astrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; brain development
Research Articles on HES-5
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Product Notes
The HES-5 hes5 (Catalog #AAA416799) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-HES-5 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HES-5 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Recommended dilutions: ELISA: 1:10,000 WB: 1:500 - 1:1000 Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Researchers should empirically determine the suitability of the HES-5 hes5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HES-5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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