Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7603751 (RTF1 antibody) at dilution of 1:50)
Rabbit RTF1 Polyclonal Antibody | anti-RTF1 antibody
RTF1 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7603751 (RTF1 antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7603751 (RTF1 antibody) at dilution of 1:50)
Western Blot (WB)
(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7603751 (RTF1 antibody) at dilution of 1:300)
Western Blot (WB)
(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7603751 (RTF1 antibody) at dilution of 1:300)
NCBI and Uniprot Product Information
NCBI Description
This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010]
Uniprot Description
RTF1: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of MLL1; it promotes leukemogenesis though association with MLL-rearranged oncoproteins, such as MLL-MLLT3/AF9 and MLL-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single- stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: nucleolus
Molecular Function: protein binding; single-stranded DNA binding
Biological Process: blastocyst growth; endodermal cell fate commitment; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter; stem cell maintenance; transcription initiation; Wnt receptor signaling pathway
Disease: Congenital Disorder Of Glycosylation, Type In
Research Articles on RTF1
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Product Notes
The RTF1 rtf1 (Catalog #AAA7603751) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RTF1 Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's RTF1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the RTF1 rtf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RTF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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