Rabbit anti-Mouse HDAC11 Polyclonal Antibody | anti-HDAC11 antibody

HDAC11, ID (HDAC11, Histone deacetylase 11) (FITC)

Cat. Num. AAA6305881

• Gene Names: HDAC11; HD11
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HDAC11; Polyclonal Antibody; ID (HDAC11; Histone deacetylase 11) (FITC); Histone deacetylase 11; anti-HDAC11 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-HDAC11 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: HDAC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-226 amino acids from the Central region of human HDAC11.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HDAC11 Antibody (Center) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the HDAC11 antibody detected the HDAC11 protein (arrow).)

Related Product Information for anti-HDAC11 antibody

This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-HDAC11 antibody

Antibodies; Enzymes; Deacetylase

References

Janssen, C., et al. J. Neuropathol. Exp. Neurol. 69(6):573-581(2010). Glozak, M.A., et al. J. Biol. Chem. 284(17):11446-11453(2009). Georgopoulos, K. Nat. Immunol. 10(1):13-14(2009). Villagra, A., et al. Nat. Immunol. 10(1):92-100(2009). Fournel, M., et al. Mol. Cancer Ther. 7(4):759-768(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 217272877
• NCBI GeneID: 79885
• NCBI Accession #: NP_079103.2
• NCBI GenBank Nucleotide #: NM_024827.3
• UniProt Accession #: Q96DB2; Q9H6I7; Q9H6X3; Q9NTC9; B4DDK1
• Molecular Weight: 33,124 Da
• NCBI Official Full Name: histone deacetylase 11 isoform 1
• NCBI Official Synonym Full Names: histone deacetylase 11
• NCBI Official Symbol: HDAC11
• NCBI Official Synonym Symbols: HD11
• NCBI Protein Information: histone deacetylase 11
• UniProt Protein Name: Histone deacetylase 11
• Protein Family: Histone deacetylase
• UniProt Gene Name: HDAC11
• UniProt Synonym Gene Names: HD11

NCBI Description

This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

Uniprot Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.