Rabbit anti-Mouse HDAC11 Polyclonal Antibody | anti-HDAC11 antibody

HDAC11, ID (HDAC11, Histone deacetylase 11)

Cat. Num. AAA649518

• Gene Names: HDAC11; HD11
• Reactivity: Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: HDAC11; Polyclonal Antibody; ID (HDAC11; Histone deacetylase 11); Anti -HDAC11; anti-HDAC11 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-HDAC11 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: HDAC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-226 amino acids from the Central region of human HDAC11.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HDAC11 Antibody (Center) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the HDAC11 antibody detected the HDAC11 protein (arrow).)

Related Product Information for anti-HDAC11 antibody

This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-HDAC11 antibody

Antibodies; Abs to Histones

NCBI and Uniprot Product Information

• NCBI GI #: 217272877
• NCBI GeneID: 79885
• NCBI Accession #: NP_079103.2
• NCBI GenBank Nucleotide #: NM_024827.3
• UniProt Accession #: Q96DB2; Q9H6I7; Q9H6X3; Q9NTC9; B4DDK1
• Molecular Weight: 39,183 Da
• NCBI Official Full Name: histone deacetylase 11 isoform 1
• NCBI Official Synonym Full Names: histone deacetylase 11
• NCBI Official Symbol: HDAC11
• NCBI Official Synonym Symbols: HD11
• NCBI Protein Information: histone deacetylase 11
• UniProt Protein Name: Histone deacetylase 11
• Protein Family: Histone deacetylase
• UniProt Gene Name: HDAC11
• UniProt Synonym Gene Names: HD11
• UniProt Entry Name: HDA11_HUMAN

NCBI Description

This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

Uniprot Description

Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Ref.5

Catalytic activity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subunit structure: Interacts with HDAC6. Ref.5

Subcellular location: Nucleus. Note: Predominantly nuclear.

Tissue specificity: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.

Miscellaneous: Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

Sequence similarities: Belongs to the histone deacetylase family.

Sequence caution: The sequence BAB15127.1 differs from that shown. Reason: Erroneous termination at position 107. Translated as Gln.The sequence CAB70712.1 differs from that shown. Reason: Frameshift at positions 177, 198 and 200.