Rabbit anti-Human hCG_1646420 Polyclonal Antibody | anti-hCG_1646420 antibody

hCG_1646420, ID (CLDN25, Putative claudin-25) (APC)

Cat. Num. AAA6305703

• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: hCG_1646420; Polyclonal Antibody; ID (CLDN25; Putative claudin-25) (APC); CLDN25; Putative claudin-25; anti-hCG_1646420 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-hCG_1646420 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: hCG_1646420 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-136 amino acids from the Central region of human hCG_1646420.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(hCG_1646420 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the hCG_1646420 antibody detected the hCG_1646420 protein (arrow).)

Related Product Information for anti-hCG_1646420 antibody

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.

Product Categories/Family for anti-hCG_1646420 antibody

Antibodies; Claudin

References

Lal-Nag, M., et al. Genome Biol. 10 (8), 235 (2009): Krause, G., et al. Biochim. Biophys. Acta 1778(3):631-645(2008). Katoh, M., et al. Int. J. Mol. Med. 11(6):683-689(2003). Venter, J.C., et al. Science 291(5507):1304-1351(2001).

NCBI and Uniprot Product Information

• NCBI GI #: 157820127
• NCBI GeneID: 644672
• NCBI Accession #: NP_001094859.1
• NCBI GenBank Nucleotide #: NM_001101389.1
• UniProt Accession #: C9JDP6
• Molecular Weight: 25,394 Da
• NCBI Official Full Name: putative claudin-25
• NCBI Official Synonym Full Names: claudin 25
• NCBI Official Symbol: CLDN25
• NCBI Protein Information: putative claudin-25
• UniProt Protein Name: Putative claudin-25
• UniProt Gene Name: CLDN25
• UniProt Entry Name: CLD25_HUMAN

NCBI Description

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010]

Uniprot Description

hCG_1646420: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q23.2

Cellular Component: tight junction; plasma membrane; integral to membrane

Molecular Function: structural molecule activity