Rabbit anti-Human HBsAg Polyclonal Antibody | anti-HBsAg antibody
HBsAg Antibody FITC Conjugated
Reactivity
Human
Applications
Immunofluorescence
Purity
Purified by Protein A
Synonyms
HBsAg; Polyclonal Antibody; HBsAg Antibody FITC Conjugated; HBV major surface antigen; HBV surface antigen; Hepatitis B Virus major surface antigen; Major surface antigen; S; Human Hepatitis B Surface Antigen; anti-HBsAg antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein A
Form/Format
10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Concentration
1mgml (varies by lot)
Applicable Applications for anti-HBsAg antibody
Immunofluorescence (IF)
Application Notes
IF: 1:50-200
Conjugation
FITC
Excitation Emission
494nm 518nm
Immunogen
Human Hepatitis B Surface Antigen
Preparation and Storage
Store at 4 degree C for 12 months.
Related Product Information for anti-HBsAg antibody
Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase. Hepatitis B infection is normally identified from serological tests that detect HBsAg but as the disease progresses this antigen may no longer be present in the blood and tests for HBcAg are used. If HBsAg can be detected in the blood for longer than six months, chronic hepatitis B is identified. The antigenic determinant of the protein moiety of the HBsAg determines specific characteristics of different serotypes and provides the basis of immunodetection. HBsAg has antigenic heterogeneity, specifically, two pairs of sub specific determinants, d y and w r allow the following combinations: adw, ayw, adr, ayr.
Product Categories/Family for anti-HBsAg antibody
NCBI and Uniprot Product Information
Uniprot Description
The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein ().
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Product Notes
The HBsAg s (Catalog #AAA9460743) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HBsAg Antibody FITC Conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HBsAg can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF). IF: 1:50-200. Researchers should empirically determine the suitability of the HBsAg s for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HBsAg, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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